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Titolo:
A single computer-controlled mechanical insufflation allows determination of the pressure-volume relationship of the respiratory system
Autore:
Svantesson, C; Drefeldt, B; Sigurdsson, S; Larsson, A; Brochard, L; Jonson, B;
Indirizzi:
Univ Lund Hosp, Dept Clin Physiol, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 Clin Physiol, SE-22185 Lund, Sweden Univ Lund Hosp, Dept Anaesthesiol & Intens Care, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 & Intens Care, SE-22185 Lund, Sweden Univ Paris 12, Hop Henri Mondor, INSERM,U296, Med Intens Care Unit, F-94010 Univ Paris 12 Creteil France F-94010 U296, Med Intens Care Unit, F-94010
Titolo Testata:
JOURNAL OF CLINICAL MONITORING AND COMPUTING
fascicolo: 1, volume: 15, anno: 1999,
pagine: 9 - 16
SICI:
1387-1307(199901)15:1<9:ASCMIA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISTRESS SYNDROME; VENTILATED PATIENTS; CURVES; RECRUITMENT; OCCLUSION; ARDS;
Keywords:
compliance; human; lung; mechanical ventilation; mechanics; resistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Jonson, B Univ Lund Hosp, Dept Clin Physiol, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 iol, SE-22185 Lund, Sweden
Citazione:
C. Svantesson et al., "A single computer-controlled mechanical insufflation allows determination of the pressure-volume relationship of the respiratory system", J CLIN M C, 15(1), 1999, pp. 9-16

Abstract

Objective. To evaluate and further develop a method for determination and mathematical characterisation of the elastic pressure-volume (P-el-V) relationship in mechanically ventilated human subjects during one single modi edinsufflation with simultaneous determination of resistance of the respiratory system. Subjects. Eight adult non-smoking human subjects without heart,lung, or thoracic cage disease scheduled for non-thoracic surgery. The study was performed in anaesthetised and muscle-relaxed subjects. Measurementsand Main Results. The P-el-V curve was determined with a computer-controlled Servo Ventilator 900C during a modified insufflation with either constant or sinusoidally varying flow. Pressure and flow were measured with the built-in sensors of the ventilator. Tracheal pressure (P-tr) was calculated by subtracting the pressure drop over the tracheal tube. The elastic recoil pressure in the peripheral lung, P-el, was obtained from the calculated P-tr by subtracting the pressure drop over the airways. P-tr was also directlymeasured through a catheter. The calculated P-tr gave similar results as the directly measured P-tr, thus indicating the reliability of the signal originating from the ventilator sensor for computation of downstream pressures. The inflection points of the sigmoidal P-el-V curve and the compliance of the linear segment were determined with high reproducibility. Conclusions. Using one single modified insufflation allows a fast and accurate determination of respiratory mechanics. The P-el-V curves were determined with high reproducibility and were adequately described by a three-segment model ofthe curve incorporating a linear segment between two asymmetrical non-linear segments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:24:47