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Titolo:
The p56(lck)-interacting protein p62 stimulates transcription via the SV40enhancer
Autore:
Rachubinski, RA; Marcus, SL; Capone, JP;
Indirizzi:
McMaster Univ, Dept Biochem, Hamilton, ON L8N 3Z5, Canada McMaster Univ Hamilton ON Canada L8N 3Z5 em, Hamilton, ON L8N 3Z5, Canada Univ Alberta, Dept Cell Biol, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 iol, Edmonton, AB T6G 2H7, Canada
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 26, volume: 274, anno: 1999,
pagine: 18278 - 18284
SICI:
0021-9258(19990625)274:26<18278:TPPPST>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHOTYROSINE-INDEPENDENT LIGAND; MURINE PERITONEAL-MACROPHAGES; UBIQUITOUS NUCLEAR PROTEINS; A170 STRESS PROTEIN; BINDING-PROTEIN; SH2 DOMAIN; MAMMALIAN-CELLS; INVITRO BINDING; GENE; ELEMENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Capone, JP McMaster Univ, Dept Biochem, 1200 Main St W, Hamilton, ON L8N 3Z5, Canada McMaster Univ 1200 Main St W Hamilton ON Canada L8N 3Z5 Canada
Citazione:
R.A. Rachubinski et al., "The p56(lck)-interacting protein p62 stimulates transcription via the SV40enhancer", J BIOL CHEM, 274(26), 1999, pp. 18278-18284

Abstract

p62 is a recently identified ubiquitin-binding, cytosolic phosphoprotein that interacts with several signal transduction molecules including the tyrosine kinase p56(lck) and the protein kinase C-zeta, p62 is therefore suggested to serve an important role in signal transduction in the cell, althoughthe physiological function of p62 remains undefined. Here we demonstrate by transient transfection assays that p62 stimulates the transcription of reporter genes linked to the simian virus 40 (SV40) enhancer. A putative p62-responsive element was localized to the B domain of the distal 72-base pairrepeat of the SV40 enhancer. p62 was unable to bind this element in vitro,nor was it able to activate transcription when directly tethered to a promoter, suggesting that p62 stimulates transcription via an indirect mechanism. Stimulation of transcription mediated by p62 was dependent on its amino-terminal region, which is also necessary for interaction with cell surface signaling molecules. These findings indicate that p62 may link extracellular signals directly to transcriptional responses, and identify the SV40 enhancer as a downstream target for signal transduction pathways in which p62 participates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:34:17