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Titolo:
The role of genetic factors in the etiology of seasonal affective disorderand seasonality
Autore:
Sher, L; Goldman, D; Ozaki, N; Rosenthal, NE;
Indirizzi:
NIMH, Clin Psychobiol Branch, Bethesda, MD 20892 USA NIMH Bethesda MD USA20892 Clin Psychobiol Branch, Bethesda, MD 20892 USA NIAAA, Neurogenet Lab, Rockville, MD 20852 USA NIAAA Rockville MD USA 20852 AAA, Neurogenet Lab, Rockville, MD 20852 USA Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi 47011, Japan Fujita Hlth Univ Toyoake Aichi Japan 47011 t, Toyoake, Aichi 47011, Japan
Titolo Testata:
JOURNAL OF AFFECTIVE DISORDERS
fascicolo: 3, volume: 53, anno: 1999,
pagine: 203 - 210
SICI:
0165-0327(199906)53:3<203:TROGFI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER GENE; META-CHLOROPHENYLPIPERAZINE; FUNCTIONAL POLYMORPHISM; BEHAVIORAL-RESPONSES; WINTER DEPRESSION; BIPOLAR DISORDER; PREVALENCE; PROMOTER; LIGHT; MOOD;
Keywords:
seasonal affective disorder; seasonality; depression; genetics;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Sher, L NIMH,0892n Psychobiol Branch, 10 Ctr Dr,Bldg 10,Room 3S-231, Bethesda, MD 2 NIMH 10 Ctr Dr,Bldg 10,Room 3S-231 Bethesda MD USA 20892 sda, MD 2
Citazione:
L. Sher et al., "The role of genetic factors in the etiology of seasonal affective disorderand seasonality", J AFFECT D, 53(3), 1999, pp. 203-210

Abstract

The study of the genetic basis of seasonal affective disorder (SAD), a condition where depressions in fall and winter alternate with nondepressed periods in the spring and summer, has recently received attention. The data onthe genetics of seasonal affective disorders are of three types: 1. Familiality: Studies on the prevalence of psychiatric disorders among relatives of patients with SAD suggested a familial contribution to the development ofSAD; 2. Heritability: A survey of a cohort of twins showed that genetic effects exert a global influence across a variety of behavioral traits and accounted for at least 29% of the variance in seasonality in men and women; 3. Molecular genetic research: two genetic variants related to serotonergic transmission, the 5-HTTLPR and the 5-HT2A-1438G/A gene promoter polymorphisms, are associated with SAD; the former but not the latter polymorphism is related to seasonality Future research may clarify the role of different genes in the development of SAD. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 10:45:55