Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Different stimulating effects of complement C3b and complete Freund's adjuvant on antibody response
Autore:
Villiers, MB; Villiers, CL; Laharie, AM; Marche, PN;
Indirizzi:
Univbleenoble 1, INSERM U238, DBMS ICH, CEA G,Lab Immunochim, F-38054 Greno Univ Grenoble 1 Grenoble France 9 H, CEA G,Lab Immunochim, F-38054 Greno
Titolo Testata:
IMMUNOPHARMACOLOGY
fascicolo: 1-3, volume: 42, anno: 1999,
pagine: 151 - 157
SICI:
0162-3109(199905)42:1-3<151:DSEOCC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-TRANSDUCTION COMPLEX; HUMORAL IMMUNE-RESPONSE; T-DEPENDENT ANTIGEN; B-CELL RESPONSE; TETANUS TOXIN; GERMINAL-CENTERS; COVALENT BINDING; EXPRESSION; LYMPHOCYTES; RECEPTOR-1;
Keywords:
immune response; complement; C3; adjuvant; antibodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Villiers, MB Univs,renoble 1, INSERM U238, DBMS ICH, CEA G,Lab Immunochim,17 Rue Martyr Univ Grenoble 1 17 Rue Martyrs Grenoble France 9 Rue Martyr
Citazione:
M.B. Villiers et al., "Different stimulating effects of complement C3b and complete Freund's adjuvant on antibody response", IMMUNOPHARM, 42(1-3), 1999, pp. 151-157

Abstract

Upon activation, complement C3 undergoes a conformational change and acquires the capacity to covalently bind to other proteins such as antigen and to interact with specific receptors; therefore, C3 is involved in cell mediated immune response. The adjuvant effect produced by linking C3-fragments to antigen has recently been described. We injected C3b-Ag complexes consisting of one molecule of C3b ester linked to one molecule of HEL to immunisedmice, and we compared the C3b adjuvant activity with that of complete Freund's adjuvant. IgG titers elicited by HEL emulsified in CFA (HEL + CFA) were higher than those elicited by HEL-C3b, but decreased rapidly after a peakresponse around day 45 whereas HEL-C3b resulted in a continuous increase of anti-MEL response. Mice immunised with HEL + CFA then boosted with HEL-C3b gave significantly higher response than those boosted with HEL + CFA, indicating more efficient memory cell restimulation by C3b. HEL + CFA leads tobetter priming than HEL-C3b when mice are boosted with HEL-C3b. Thus, adjuvant effect of C3b is different from that of CFA, leading to more stable IgG production and better memory stimulation. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:00:27