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Titolo:
Immunomodulation by viruses: the myxoma virus story
Autore:
Nash, P; Barrett, J; Cao, JX; Hota-Mitchell, S; Lalani, AS; Everett, H; Xu, XM; Robichaud, J; Hnatiuk, S; Ainslie, C; Seet, BT; McFadden, G;
Indirizzi:
Robarts Res Inst, London, ON N6G 2V4, Canada Robarts Res Inst London ON Canada N6G 2V4 nst, London, ON N6G 2V4, Canada Univ Western Ontario, Dept Microbiol & Immunol, London, ON, Canada Univ Western Ontario London ON Canada biol & Immunol, London, ON, Canada Univ Alberta, Dept Biochem, Edmonton, AB, Canada Univ Alberta Edmonton ABCanada erta, Dept Biochem, Edmonton, AB, Canada
Titolo Testata:
IMMUNOLOGICAL REVIEWS
, volume: 168, anno: 1999,
pagine: 103 - 120
SICI:
0105-2896(199904)168:<103:IBVTMV>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERINE PROTEINASE-INHIBITOR; SHOPE FIBROMA VIRUS; EPIDERMAL GROWTH-FACTOR; TNF-RECEPTOR HOMOLOG; INTERFERON-GAMMA RECEPTOR; CD4 DOWN-REGULATION; SERPIN-LIKE PROTEIN; VACCINIA VIRUS; FACTOR-ALPHA; ENDOPLASMIC-RETICULUM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
118
Recensione:
Indirizzi per estratti:
Indirizzo: McFadden, G Robarts Res Inst, 1400 Western Rd,SDRI 133, London, ON N6G 2V4, Canada Robarts Res Inst 1400 Western Rd,SDRI 133 London ON Canada N6G 2V4
Citazione:
P. Nash et al., "Immunomodulation by viruses: the myxoma virus story", IMMUNOL REV, 168, 1999, pp. 103-120

Abstract

Myxoma virus is a poxvirus pathogen of rabbits that has evolved to replicate successfully in the presence of an active immune response by an infectedhost. To accomplish this, the virus has developed a variety of strategies to avoid detection by or obstruct specific aspects of the antiviral response whose consolidated action is antagonistic to virus survival. We describe two distinct viral strategies carried out by viral proteins with which myxoma virus subverts the host immune response. The first strategy is the production of virus-encoded proteins known as viroceptors or virokines that mimic host receptors or cytokines. These seek to actively block extracellular immune signals required for effective virus clearance and produce a local environment in the infected tissue that is "virus friendly". The second strategy carried out by intracellular viral proteins, seeks to retard the innateantiviral responses such as apoptosis, and kinder attempts by the infectedcell to communicate with the cellular arm of the immune system. By studying these viral strategies of immune evasion, the myxoma system can provide insights into virus-host interactions and also provide new insights into thecomplex immune system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 20:17:46