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Titolo:
ASSOCIATION OF KETAMINE-INDUCED PSYCHOSIS WITH FOCAL ACTIVATION OF THE PREFRONTAL CORTEX IN HEALTHY-VOLUNTEERS
Autore:
BREIER A; MALHOTRA AK; PINALS DA; WEISENFELD NI; PICKAR D;
Indirizzi:
NIMH,EXPT THERAPEUT BRANCH,BLDG 10,RM 4N212,9000 ROCKVILLE PIKE ROCKVILLE MD 20892
Titolo Testata:
The American journal of psychiatry
fascicolo: 6, volume: 154, anno: 1997,
pagine: 805 - 811
SICI:
0002-953X(1997)154:6<805:AOKPWF>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL GLUCOSE-UTILIZATION; BLOOD-FLOW; CHRONIC-SCHIZOPHRENIA; BRAIN MEMBRANES; PET IMAGES; RAT-BRAIN; PHENCYCLIDINE; HYPOFRONTALITY; HALLUCINATIONS; METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
A. Breier et al., "ASSOCIATION OF KETAMINE-INDUCED PSYCHOSIS WITH FOCAL ACTIVATION OF THE PREFRONTAL CORTEX IN HEALTHY-VOLUNTEERS", The American journal of psychiatry, 154(6), 1997, pp. 805-811

Abstract

Objective: Agents that antagonize the N-methyl-D-aspartic acid (NMDA)receptor, such as phencyclidine and ketamine, produce an acute psychotic state in normal individuals that resembles some symptoms of schizophrenia. The aim of this study was to determine which brain regions are involved in NMA receptor-mediated psychosis. Method: Positron emission tomography with [F-18]fluorodeoxyglucose was used to determine cerebral metabolic activity in 17 healthy volunteers while an acute psychotic state was induced simultaneously by the administration of subanesthetic doses of ketamine. Results: Ketamine produced focal increases inmetabolic activity in the prefrontal cortex and an acute psychotic state. A change in one psychotic symptom, conceptual disorganization, was significantly related to prefrontal activation. Conclusions: These data suggest that the prefrontal cortex may be involved in mediating NMDA receptor-induced psychosis.

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Documento generato il 04/04/20 alle ore 07:34:57