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Titolo:
Regulation of hematopoiesis in a sea of chemokine family members with a plethora of redundant activities
Autore:
Broxmeyer, HE; Kim, CH;
Indirizzi:
Indiana Univ, Sch Med, Walther Oncol Ctr, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 ol Ctr, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Microbiol Immunol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 mmunol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 pt Med, Indianapolis, IN 46202 USA Walther Canc Inst, Indianapolis, IN USA Walther Canc Inst Indianapolis INUSA er Canc Inst, Indianapolis, IN USA
Titolo Testata:
EXPERIMENTAL HEMATOLOGY
fascicolo: 7, volume: 27, anno: 1999,
pagine: 1113 - 1123
SICI:
0301-472X(199907)27:7<1113:ROHIAS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA; MYELOID PROGENITOR CELLS; HUMAN CC-CHEMOKINE; GRANULOCYTE CHEMOTACTIC PROTEIN-2; GENETICALLY-ENGINEERED VARIANT; HUMAN-BONE-MARROW; MESSENGER-RNA EXPRESSION; COLONY FORMATION INVITRO; SIGNAL SEQUENCE TRAP; HUMAN BETA-CHEMOKINE;
Keywords:
chemokines; chemokine receptors; stem progenitor cells; hematopoiesis; chemotaxis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
149
Recensione:
Indirizzi per estratti:
Indirizzo: Broxmeyer, HE Indianaapolis,Sch Med, Walther Oncol Ctr, 1044 W Walnut St,Room 302, Indian Indiana Univ 1044 W Walnut St,Room 302 Indianapolis IN USA 46202
Citazione:
H.E. Broxmeyer e C.H. Kim, "Regulation of hematopoiesis in a sea of chemokine family members with a plethora of redundant activities", EXP HEMATOL, 27(7), 1999, pp. 1113-1123

Abstract

The field of chemokine biology is a rapidly advancing one, with over 50 chemokines identified that mediate their effects through one or more of 16 different chemokine receptors, Chemokines, originally identified as chemotactic cytokines, manifest a number of functions, including modulation of bloodcell production at the level of hematopoietic stem/progenitor cells and the directed movement of these early blood cells. This report reviews chemokines and chemokine/receptor activities mainly in the context of hematopoietic cell regulation and the numerous chemokines that manifest suppressive activity on proliferation of stem/progenitor cells. This is contrasted with the specificity of only a few chemokines for the chemotaxis of these early cells, The large number of chemokines with suppressive activity is hypothesized to reflect the different cell, tissue, and organ sites of production of these chemokines and the need to control stem/progenitor cell proliferationin different organ sites throughout the body. (C) 1999 International Society for Experimental Hematology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:35:05