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Titolo:
Proton MRS in neurological disorders
Autore:
Bonavita, S; Di Salle, F; Tedeschi, G;
Indirizzi:
Univ Naples 2, Inst Neurol Sci, I-80131 Naples, Italy Univ Naples 2 Naples Italy I-80131 nst Neurol Sci, I-80131 Naples, Italy
Titolo Testata:
EUROPEAN JOURNAL OF RADIOLOGY
fascicolo: 2, volume: 30, anno: 1999,
pagine: 125 - 131
SICI:
0720-048X(199905)30:2<125:PMIND>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; TEMPORAL-LOBE EPILEPSY; IN-VIVO; MULTIPLE-SCLEROSIS; H-1-NMR SPECTROSCOPY; ALZHEIMERS-DISEASE; AXONAL DAMAGE; NEURONAL LOSS; BRAIN; METABOLITE;
Keywords:
proton magnetic resonance spectroscopy; neurological disorders; metabolic disturbances;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Bonavita, S Univ Naples 2, Inst Neurol Sci, Via Pansini 5, I-80131 Naples,Italy Univ Naples 2 Via Pansini 5 Naples Italy I-80131 aples, Italy
Citazione:
S. Bonavita et al., "Proton MRS in neurological disorders", EUR J RAD, 30(2), 1999, pp. 125-131

Abstract

Proton magnetic resonance spectroscopy (H-1 MRS) permits the acquisition of the signal arising from several brain metabolites. Pit long echo-time (TE) H-1 MRS can detect N-acetyl-aspartate containing compounds, choline containing compounds, creatine + phosphocreatine and lactate. At short TE, lipids, tryglicerides, alanine, glutamate, glutamine, GABA, scyllo-inositol, glucose, myo-inositol, carnosine and histydine are visible. H-1 MRS can be performed with single-voxel, multivoxel, single slice and multislice techniques. With single voxel H-1 MRS it is possible to measure metabolites relaxation time. which allows the measurement of metabolite concentrations. This technique can be useful in the study of focal lesions in the central nervous system (CNS) such as epilepsy (pre-surgical identification of epileptic focus), brain tumors (evaluation of recurrence and radiation necrosis), stroke, multiple sclerosis, etc. Single slice and multislice H-1 MRS imaging (H-1MRSI) can be performed only at long TE and permits the mapping of the brain metabolites distribution which makes them particularly useful in studyingdiffuse diseases and heterogeneous lesions of the CNS. H-1 MRS can also beuseful in the evaluation of 'ischemic penumbra' of stroke; developmental (myelin and neuronal dysgenesis); head trauma (evaluation of cerebral damagenot visible with MRI); degenerative disorders (identification of microscopic pathology not visible with MRI); and metabolic diseases (metabolic disturbances with specific metabolic patterns). (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 19:10:00