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Titolo:
Anorectic efficacy of the fenfluramine phentermine combination in rats: additivity or synergy?
Autore:
Roth, JD; Rowland, NE;
Indirizzi:
Univ Florida, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 Florida, Gainesville, FL 32611 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 373, anno: 1999,
pagine: 127 - 134
SICI:
0014-2999(19990604)373:2-3<127:AEOTFP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-WEIGHT; DRUGS; 5-HT;
Keywords:
dexfenfluramine; phentermine; synergy; deprivation; anorectic agent;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Rowland, NE Univ Florida, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 inesville, FL 32611 USA
Citazione:
J.D. Roth e N.E. Rowland, "Anorectic efficacy of the fenfluramine phentermine combination in rats: additivity or synergy?", EUR J PHARM, 373(2-3), 1999, pp. 127-134

Abstract

Fenfluramine + phentermine was a widely used combination for weight loss. Fenfluramine and phentermine are believed to act via serotonin and catecholamines, respectively. To what extent these drugs interact has not been well-established. We compared the anorectic efficacy of a range of doses of thecombination (using dexfenfluramine instead of fenfluramine) relative to a range of doses of the individual drugs in 90 min sweetened milk intake tests in deprived and nondeprived rats. Results were plotted on isobolograms todetermine whether the anorectic effects of the combination were either additive or synergistic. Collectively, the isobolographic analysis revealed that: (1) under acute conditions, dexfenfluramine and phentermine interact for the most part in a synergistic manner, and (2) with the exception of phentermine alone, deprivation state at time of testing did not alter the efficacy of the anorectics. These findings suggest that combined drug treatment for obesity is a theoretical approach that merits further investigation. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 30/03/20 alle ore 09:01:51