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Titolo:
Vulvar carcinoma in young patients and its relationship with genital warts
Autore:
Traiman, P; Bacchi, CE; De Luca, LA; Uemura, G; Neto, JN; Nahas, EAP; Pontes, A;
Indirizzi:
UNESP, Fac Med, Dept Obstet & Ginecol, BR-18618000 Botucatu, SP, Brazil UNESP Botucatu SP Brazil BR-18618000 BC, BR-18618000 Botucatu, SP, Brazil UNESP, Dept Pathol, BR-18618000 Botucatu, SP, Brazil UNESP Botucatu SP Brazil BR-18618000 BC, BR-18618000 Botucatu, SP, Brazil
Titolo Testata:
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
fascicolo: 3, volume: 20, anno: 1999,
pagine: 191 - 194
SICI:
0392-2936(1999)20:3<191:VCIYPA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; WOMEN; CANCER; TUMORS;
Keywords:
in situ hybridization; HPV; vulvar; carcinoma; young patients;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Traiman, P UNESP, Fac Med, Dept Obstet & Ginecol, BR-18618000 Botucatu, SP, Brazil UNESP Botucatu SP Brazil BR-18618000 BC00 Botucatu, SP, Brazil
Citazione:
P. Traiman et al., "Vulvar carcinoma in young patients and its relationship with genital warts", EUR J GYN O, 20(3), 1999, pp. 191-194

Abstract

We report the occurrence of aggressive vulvar carcinoma associated with condyloma acuminata in three patients: under 33 years old. Discussion of the role of the human papilloma virus (HPV) in the development of vulvar canceris also presented. Three patients with condyloma associated with aggressive vulvar squamous cell carcinoma, in situ (1 case) and invasive (2 cases), documented by biopsy and/or vulvectomy are presented. In situ hybridization(ISH) was used to characterize the subtypes of HPV. One patient with erythematous systemic lupus developed in situ carcinoma after 5 years. The othertwo cases also developed aggressive multicentric, invasive squamous cell carcinoma after 10 years of diagnosis of condyloma. In all cases HPV cytological abnormalities were seen throughout the pathological examination. HPV 16 and 18 were present in cells of invasive squamous cell carcinoma in cases2 and 3. HPV 6 and 11 were detected only in the condyloma area in case 2. HPV 30 was seen only in the condyloma area in case 3. This report emphasizes the need for biopsies of all unusually persistent or treatment-resistant condylomas, particularly in young and/or immunoisuppressed patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:49:42