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Titolo:
SKELETAL-MUSCLE ALTERATIONS IN PATIENTS WITH CHRONIC HEART-FAILURE
Autore:
SCHAUFELBERGER M; ERIKSSON BO; GRIMBY G; HELD P; SWEDBERG K;
Indirizzi:
OSTRA UNIV HOSP,DEPT MED S-41685 GOTHENBURG SWEDEN OSTRA UNIV HOSP,DEPT PEDIAT S-41685 GOTHENBURG SWEDEN GOTHENBURG UNIV,SAHLGRENSKA UNIV HOSP,DEPT REHABIL MED GOTHENBURG SWEDEN
Titolo Testata:
European heart journal
fascicolo: 6, volume: 18, anno: 1997,
pagine: 971 - 980
SICI:
0195-668X(1997)18:6<971:SAIPWC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR MAGNETIC-RESONANCE; IDIOPATHIC DILATED CARDIOMYOPATHY; AEROBIC ENZYME-ACTIVITY; TUMOR-NECROSIS-FACTOR; ENERGY-METABOLISM; BLOOD-FLOW; EXERCISE; ABNORMALITIES; ENDURANCE; ELECTROLYTES;
Keywords:
HEART FAILURE; SKELETAL MUSCLE; CENTRAL HEMODYNAMICS; EXERCISE CAPACITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
M. Schaufelberger et al., "SKELETAL-MUSCLE ALTERATIONS IN PATIENTS WITH CHRONIC HEART-FAILURE", European heart journal, 18(6), 1997, pp. 971-980

Abstract

Aims To investigate skeletal muscle in patients with chronic heart failure and controls, and relate skeletal muscle variables to functionalclass, exercise capacity, central haemodynamics, muscle strength and medical treatment. Methods Biopsy from the lateral vastus muscle was obtained in 43 patients and 20 controls. Right sided heart catheterization was performed in 19 patients and maximal exercise testing in 26 patients. In nine patients muscle strength was measured. Patients had higher lactate levels, higher lactate dehydrogenase activity, and lower oxidative enzymes activity than controls. In patients, the percentage of type I fibres and capillarization were decreased while the percentage of type II B fibres were increased. Lactate dehydrogenase activity correlated with exercise capacity, muscle strength and right atrial pressure. Digoxin-treated patients had significantly lower oxidative enzyme activity than patients without digoxin treatment. Conclusion Patients with chronic heart failure have several skeletal muscle abnormalities. Central haemodynamics and medical treatment may, in addition to inactivity, be important in skeletal muscle changes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:40:20