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Titolo:
Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner
Autore:
Lama, J; Mangasarian, A; Trono, D;
Indirizzi:
CMU, Dept Genet & Microbiol, CH-1211 Geneva 4, Switzerland CMU Geneva Switzerland 4 enet & Microbiol, CH-1211 Geneva 4, Switzerland La Jolla Inst Allergy & Immunol, Mol Immunol Div, San Diego, CA 92121 USA La Jolla Inst Allergy & Immunol San Diego CA USA 92121 iego, CA 92121 USA
Titolo Testata:
CURRENT BIOLOGY
fascicolo: 12, volume: 9, anno: 1999,
pagine: 622 - 631
SICI:
0960-9822(19990617)9:12<622:CEOCRH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; ENVELOPE GLYCOPROTEIN; CYTOPLASMIC DOMAIN; PLASMA-MEMBRANE; DOWN-REGULATION; LENTIVIRAL VECTOR; REVERSE TRANSCRIPTION; ENDOPLASMIC-RETICULUM; INDUCED DEGRADATION; GENE DELIVERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Trono, D CMU, Dept Genet & Microbiol, 9 Ave Champel, CH-1211 Geneva 4, Switzerland CMU 9 Ave Champel Geneva Switzerland 4 211 Geneva 4, Switzerland
Citazione:
J. Lama et al., "Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner", CURR BIOL, 9(12), 1999, pp. 622-631

Abstract

Background: Human immunodeficiency virus-1 (HIV-1) infection decreases thecell-surface expression of its cellular receptor, CD4, through the combined actions of Nef, Env and Vpu, Such functional convergence strongly suggests that CD4 downregulation is critical for optimal viral replication, yet the significance of this phenomenon has so far remained a puzzle. Results: We show that high levels of CD4 on the surface of HIV-infected cells induce a dramatic reduction in the infectivity of released virions by the sequestering of the viral envelope by CD4. CD4 is able to accumulate in viral particles while at the same time blocking incorporation of Env into the virion. Nef and Vpu, through their ability to downregulate CD4, counteract this effect. Conclusions: The CD4-mediated 'envelope interference' described here probably explains the plurality of mechanisms developed by HIV to downregulate the cell-surface expression of its receptor. (C) Elsevier Science Ltd ISSN 0960-9822.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:09:54