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Titolo:
Rat and human membrane dipeptidase: tissue distribution and developmental changes
Autore:
Kera, Y; Liu, Z; Matsumoto, T; Sorimachi, Y; Nagasaki, H; Yamada, RH;
Indirizzi:
Nagaokapaniv Technol, Dept Environm Syst Engn, Nagaoka, Niigata 9402188, Ja Nagaoka Univ Technol Nagaoka Niigata Japan 9402188 a, Niigata 9402188, Ja Nagaoka Univ Technol, Dept Bioengn, Nagaoka, Niigata 9402188, Japan Nagaoka Univ Technol Nagaoka Niigata Japan 9402188 Niigata 9402188, Japan Kyoto Prefectural Univ Med, Dept Legal Med, Kyoto 6020841, Japan Kyoto Prefectural Univ Med Kyoto Japan 6020841 Med, Kyoto 6020841, Japan Doshishaanomens Coll Liberal Arts, Dept Food Sci & Nutr, Kyoto 6020893, Jap Doshisha Womens Coll Liberal Arts Kyoto Japan 6020893 Kyoto 6020893, Jap
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
fascicolo: 1, volume: 123, anno: 1999,
pagine: 53 - 58
SICI:
0305-0491(199905)123:1<53:RAHMDT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MICROSOMAL DIPEPTIDASE; HUMAN RENAL DIPEPTIDASE; DEHYDROPEPTIDASE-I; MOLECULAR-CLONING; LUNG DIPEPTIDASE; PURIFICATION; ENZYMES; LEUKOTRIENE-D4; CILASTATIN;
Keywords:
membrane dipeptidase; hydrolysis of Gly-D-Ala; cilastatin sensitive; tissue distribution; developmental changes; rat; human; autopsy; healthy volunteers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Yamada, RH Nagaokapaniv Technol, Dept Environm Syst Engn, Nagaoka, Niigata9402188, Ja Nagaoka Univ Technol Nagaoka Niigata Japan 9402188 9402188, Ja
Citazione:
Y. Kera et al., "Rat and human membrane dipeptidase: tissue distribution and developmental changes", COMP BIOC B, 123(1), 1999, pp. 53-58

Abstract

Distribution and developmental changes in membrane dipeptidase activity were examined in rat and human tissues. The activity to hydrolyze glycyl-D-alanine in rat and human tissues was completely or almost completely inhibited by 5 mM cilastatin, suggesting that the activity was due to membrane dipeptidase and that the contribution of leucine aminopeptidase to the activitywas minor. In 8-week-old rats, the activity was high in lung, kidney, pancreas and testis, and in each pooled sample of ileal mucosa, duodenal mucosa, jejunal mucosa and adrenal mucosa. A low activity was found in spleen, liver, serum and heart. The activity in lung, kidney, adrenal and intestinal mucosa increased up to the age of 5 or 8 weeks, while that in pancreas, testis and spleen reached a maximal level at around 3 weeks and declined thereafter. The distribution profile of the enzyme in postmortem tissues of adult humans was similar to that in rat, except for an extremely low activity in lung. The enzyme was also found in serum and urine from healthy volunteers. In urine, the activity was significantly correlated to the creatinine content. No clear dependence of the activity on gender or age was observed inurine and serum. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:25:45