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Titolo:
Studies on synthesis and degradation properties of polyanhydrides with hexestrol in the backbone
Autore:
Zhou, CJ; Fan, CL; Hu, YH; Zhuo, RX;
Indirizzi:
Wuhan Univ, Coll Chem, Wuhan 430072, Peoples R China Wuhan Univ Wuhan Peoples R China 430072 m, Wuhan 430072, Peoples R China
Titolo Testata:
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
fascicolo: 6, volume: 20, anno: 1999,
pagine: 990 - 992
SICI:
0251-0790(199906)20:6<990:SOSADP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
CHI
Keywords:
polymer-controlled drug release systems; polyesteranhydrides; melt-polycondensation; hexestrol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Fan, CL Wuhan Univ, Coll Chem, Wuhan 430072, Peoples R China Wuhan Univ Wuhan Peoples R China 430072 430072, Peoples R China
Citazione:
C.J. Zhou et al., "Studies on synthesis and degradation properties of polyanhydrides with hexestrol in the backbone", CHEM J CH U, 20(6), 1999, pp. 990-992

Abstract

Polymeric drug containing active agent in the backbone was one of the controlled release systems. In this paper, some polymers, which have an antineoplastic agent(hexestrol) in the backbone, have been synthesized by copolymerization hexestrol bis(hydrogen succinate) with sebacic acid(SA). Hexestrolbis(hydrogen succinate) was prepared by reaction hexestrol with succinic anhydride. The degradation properties in vitro under various pH conditions were also investigated. The results showed that the degradation rates increase with the increase of PH, and at the same time, the degradation rates increase with the increase in sebacic acid content in the copolymers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:54:24