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Titolo:
An update on the mechanisms of action of the peroxisome proliferator-activated receptors (PPARs) and their roles in inflammation and cancer
Autore:
Gelman, L; Fruchart, JC; Auwerx, J;
Indirizzi:
Inst Pasteur, Dept Atherosclerose, LBRE, INSERM U325, F-59019 Lille, France Inst Pasteur Lille France F-59019 RE, INSERM U325, F-59019 Lille, France
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 6-7, volume: 55, anno: 1999,
pagine: 932 - 943
SICI:
1420-682X(199906)55:6-7<932:AUOTMO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; BINDING-PROTEIN-ALPHA; RETINOID-X-RECEPTOR; SMOOTH-MUSCLE CELLS; HUMAN BREAST-CANCER; OB GENE-EXPRESSION; FACTOR KAPPA-B; FATTY-ACIDS; ADIPOCYTE DIFFERENTIATION; NUCLEAR RECEPTORS;
Keywords:
PPAR; nuclear receptor; lipid homeostasis; cofactor; inflammation; tumorigenesis; apoptosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
140
Recensione:
Indirizzi per estratti:
Indirizzo: Auwerx, J Inst Pasteur, Dept Atherosclerose, LBRE, INSERM U325, Rue Calmette, F-59019 Inst Pasteur Rue Calmette Lille France F-59019 almette, F-59019
Citazione:
L. Gelman et al., "An update on the mechanisms of action of the peroxisome proliferator-activated receptors (PPARs) and their roles in inflammation and cancer", CELL MOL L, 55(6-7), 1999, pp. 932-943

Abstract

Peroxisome proliferator-activated receptors (PPARs) art: nuclear receptorsand have been initially described as molecular targets for compounds whichinduce peroxisome proliferation. The interest of researchers for PPARs increased dramatically when these receptors were shown to be directly activated by a number of medically relevant compounds. These compounds include: thefibrate class of hypolidemic drugs, the thiazolidinediones, which are insulin sensitizers used as orally active antidiabetic agents, certain non-steroidal anti-inflammatory drugs (NSAIDs), and naturally occurring fatty acid-derived molecules. Rapidly, it was demonstrated that PPARs are key regulators of lipid homeostasis and provide a molecular link between nutrition and gene regulation. Recently. detailed studies of PPAR expression profiles in different tissues pointed to the roles these receptors play in inflammationcontrol and cell proliferation.. In this review we will focus on the new insights gained into these two areas and we will also discuss our current knowledge of the regulation of PPAR transcriptional activity by cofactors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:13:01