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Titolo:
The transcriptional activities of p53 and its homologue p51/p63: Similarities and differences
Autore:
Shimada, A; Kato, S; Enjo, K; Osada, M; Ikawa, Y; Kohno, K; Obinata, M; Kanamaru, R; Ikawa, S; Ishioka, C;
Indirizzi:
Tohokui,niv, Dept Clin Oncol, Inst Dev Aging & Canc, Aoba Ku, Sendai, Miyag Tohoku Univ Sendai Miyagi Japan Dev Aging & Canc, Aoba Ku, Sendai, Miyag Tohoku Univ, Dept Cell Biol, Inst Dev Aging & Canc, Sendai, Miyagi, Japan Tohoku Univ Sendai Miyagi Japan Dev Aging & Canc, Sendai, Miyagi, Japan Tokyo Med & Dent Univ, Dept Retroviral Regulat, Div Med Res, Tokyo 1138519, Tokyo Med & Dent Univ Tokyo Japan 1138519 t, Div Med Res, Tokyo 1138519, Nara Inst Sci & Technol, Nara 63001, Japan Nara Inst Sci & Technol Nara Japan 63001 ci & Technol, Nara 63001, Japan
Titolo Testata:
CANCER RESEARCH
fascicolo: 12, volume: 59, anno: 1999,
pagine: 2781 - 2786
SICI:
0008-5472(19990615)59:12<2781:TTAOPA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL ASSAY; CELL-LINES; P73 GENE; P53-RELATED PROTEIN; MUTATIONAL ANALYSIS; HUMAN CANCERS; DNA-DAMAGE; YEAST; NEUROBLASTOMA; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Ishioka, C Tohokuchi,v, Dept Clin Oncol, Inst Dev Aging & Canc, Aoba Ku, 4-1 Seiryo Ma Tohoku Univ 4-1 Seiryo Machi Sendai Miyagi Japan 4-1 Seiryo Ma
Citazione:
A. Shimada et al., "The transcriptional activities of p53 and its homologue p51/p63: Similarities and differences", CANCER RES, 59(12), 1999, pp. 2781-2786

Abstract

p51/p63 is a novel p53 homologue that has been shown to act as a transcriptional activator through thr p53-binding sequence of the p21/WAF1 promoter and to induce apoptosis when it is expressed transiently in a human tumor cell line. We de,eloped transcription assay systems for these two related genes in both Saccharomyces cerevisiae and mammalian cells and used them to investigate the functional similarities and differences of these genes. We found that p51/p63 trans-activated the previously identified p53 target genes, but the degree of the transactivation by p51/p63 differed from that by p53, These results suggest that the cellular signal on p51/p63 cross-talks partially but not completely with that of the p53 pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 19:01:05