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Titolo:
A prospective comparison of fiberoptic transbronchial needle aspiration and bronchial biopsy for bronchoscopically visible lung carcinoma
Autore:
Govert, JA; Dodd, LG; Kussin, PS; Samuelson, WM;
Indirizzi:
Duke Univ, Med Ctr, Thorac Oncol Program, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Thorac Oncol Program, Durham, NC 27710 USA Duke Univ, Med Ctr, Div Pulm & Crit Care Med, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Pulm & Crit Care Med, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Pathol, Cytopathol Sect, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 thol, Cytopathol Sect, Durham, NC 27710 USA Univ Utah, Div Resp Crit Care & Occupat Pulm Med, Salt Lake City, UT USA Univ Utah Salt Lake City UT USA Occupat Pulm Med, Salt Lake City, UT USA
Titolo Testata:
CANCER CYTOPATHOLOGY
fascicolo: 3, volume: 87, anno: 1999,
pagine: 129 - 134
SICI:
0008-543X(19990625)87:3<129:APCOFT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHOGENIC-CARCINOMA; DIAGNOSIS; SUBMUCOSAL; CANCER;
Keywords:
lung carcinoma; endobronchial malignancy; bronchoscopy; fiberoptic bronchoscopy; transbronchial needle aspiration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Govert, JA Duke Univ, Med Ctr, Thorac Oncol Program, Box 31012, Durham, NC27710 USA Duke Univ Box 31012 Durham NC USA 27710 2, Durham, NC 27710 USA
Citazione:
J.A. Govert et al., "A prospective comparison of fiberoptic transbronchial needle aspiration and bronchial biopsy for bronchoscopically visible lung carcinoma", CANC CYTOP, 87(3), 1999, pp. 129-134

Abstract

BACKGROUND. Fiberoptic bronchoscopy is the most common modality used to diagnose endobronchial carcinoma. The authors prospectively compared the sensitivity of endobronchial needle aspiration (EBNA) and immediate cytologic assessment with bronchial biopsy and bronchial washing in the diagnosis of endobronchial malignancy. METHODS. A prospective trial comparing the sensitivity of EBNA, bronchial biopsy, and bronchial washings during fiberoptic bronchoscopy for endobronchially visible lung tumor was conducted. The authors enrolled 65 consecutive patients with endobronchial abnormalities identified during bronchoscopy. All patients in the study underwent fiberoptic bronchoscopy that included EBNA, bronchial biopsy, and bronchial wash. The sensitivities of the individual techniques were compared. The sensitivities of bronchoscopy were also prospectively compared when multiple sampling techniques were employed. RESULTS. Malignancy was present in 57 of 65 study patients. Cancer was diagnosed in 47 patients by EBNA, 42 patients by bronchial biopsy, and 36 patients by bronchial washing. The sensitivity of a strategy employing bronchial biopsy and bronchial washings was 0.82 (95% CI, 0.70-0.90). The addition of EBNA to bronchial biopsy and bronchial washings significantly increased the sensitivity to 0.95 (95% CI, 0.85-0.98; McNemar P = 0.02). Subset analysis revealed that this strategy was especially useful in cases in which lesions were submucosal or causing extrinsic compression. CONCLUSIONS. There is a modest increase in the sensitivity of fiberoptic bronchoscopy in diagnosing endobronchial cancer with the addition of EBNA tobronchial biopsy and bronchial washings, especially for patients with submucosal abnormalities. Collection of EBNA, followed by biopsy and washings only if immediate interpretation of EBNA is negative or inadequate, may be the moat effective bronchoscopy strategy for evaluating visible endobronchial abnormalities. (C) 1999 American Cancer Society.

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Documento generato il 07/07/20 alle ore 14:05:12