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Titolo:
Effects of T-588, a newly synthesized cognitive enhancer, on hippocampal CA1 neurons in rat brain tissue slices
Autore:
Kimura, T; Tamura, R; Kurimoto, H; Ono, T;
Indirizzi:
Toyama Med & Pharmaceut Univ, Fac Med, Dept Physiol, Toyama 9300194, JapanToyama Med & Pharmaceut Univ Toyama Japan 9300194 Toyama 9300194, Japan
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 831, anno: 1999,
pagine: 175 - 183
SICI:
0006-8993(19990612)831:1-2<175:EOTANS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PYRAMIDAL CELLS; ALZHEIMERS-DISEASE; HYPOTHALAMIC NEURONS; MEMORY IMPAIRMENT; SENILE DEMENTIA; ISCHEMIA; INVITRO; HYDROCHLORIDE; MECHANISMS; SYNAPSE;
Keywords:
intracellular recording; hippocampus; acetylcholine; in vitro; whole cell voltage-clamp recording;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Ono, T Toyama9300194,harmaceut Univ, Fac Med, Dept Physiol, 2630 Sugitani,Toyama Toyama Med & Pharmaceut Univ 2630 Sugitani Toyama Japan 9300194 ma
Citazione:
T. Kimura et al., "Effects of T-588, a newly synthesized cognitive enhancer, on hippocampal CA1 neurons in rat brain tissue slices", BRAIN RES, 831(1-2), 1999, pp. 175-183

Abstract

The effects of a newly synthesized cognitive enhancer, (-)-R-alpha-[[2-(diethylamino) ethoxy] methyl] benzo [b] thiophene-5-methanol hydrochloride (T-588), on the membrane properties of hippocampal CA1 neurons were investigated in a rat brain slice preparation. T-588 produced a stow and long-lasting depolarization of CA1 neurons with an increase in membrane resistance; this action showed close similarity to that of acetylcholine (ACh). However, the action of T-588 was not affected by atropine, tetrodotoxin or DL-2-amino-5-phosphonovalerate, while the action of ACh was blocked by atropine. Theestimated reversal potential of this T-588 effect was near - 90 mV which is the reversal potential of potassium ions in CA1 neurons. In the whole-cell voltage-clamp study, T-588 produced a reversible block of the outward potassium current in CA1 neurons. T-588 did not block the afterhyperpolarization evoked by an intracellular current injection, while ACh suppressed it. These results suggest that T-588 has a direct effect on CA1 neurons independent of its cholinergic activity, resulting from blockade of a conductance carried predominantly by potassium ions. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 07:15:40