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Titolo:
DESIGNS AND SOLUTIONS TO MULTIPLE-TRAIT COMPARISONS
Autore:
WELLER JI; SONG JZ; RONIN YI; KOROL AB;
Indirizzi:
AGR RES ORG,VOLCANI CTR,INST ANIM SCI,DEPT GENET IL-50250 BET DAGAN ISRAEL UNIV HAIFA,INST EVOLUT IL-31905 HAIFA ISRAEL
Titolo Testata:
Animal biotechnology
fascicolo: 1, volume: 8, anno: 1997,
pagine: 107 - 122
SICI:
1049-5398(1997)8:1<107:DASTMC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DAIRY-CATTLE; MARKER LOCI; LINKAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
J.I. Weller et al., "DESIGNS AND SOLUTIONS TO MULTIPLE-TRAIT COMPARISONS", Animal biotechnology, 8(1), 1997, pp. 107-122

Abstract

Multiple trait detection and analysis of quantitative trait loci via linkage to genetic markers is problematic, first because of the increase in the number of comparisons tested, second because of possible multitrait loci effects, and third because of biases due to selection based on phenotypic trait values. Nearly all studies that considered multiple traits have analyzed each trait separately. Two methods have beenproposed for multitrait experiments; maximum likelihood multivariate analysis, and canonical transformation to a set of uncorrelated variables. If individuals are selected for genotyping based on a single trait, parameter estimates for other correlated traits will be biased using single trait analyses, and significance levels will be incorrect. With multivariate analysis, unbiased estimates of QTL effects can be derived even with selective genotyping. Furthermore, power is increased per individual genotyped, even if selective genotyping is relative to atrait unaffected by the segregating locus. For a preliminary multipletrait analysis, controlling the false discovery rate rather than the experimentwisetype-I error allows for greater statistical power to detect true effects. In the absence of any hue effects the two methods are equivalent. An example is given using granddaughter design data.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 03:52:34