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Titolo:
Arterial structural changes with verapamil in spontaneously hypertensive rats
Autore:
Koffi, I; Safar, ME; Labat, C; Lacolley, P; Benetos, A; Mourad, JJ;
Indirizzi:
Hop Broussais, Dept Internal Med, F-75674 Paris 14, France Hop Broussais Paris France 14 ept Internal Med, F-75674 Paris 14, France Hop Broussais, INSERM, U337, F-75674 Paris, France Hop Broussais Paris France F-75674 , INSERM, U337, F-75674 Paris, France
Titolo Testata:
AMERICAN JOURNAL OF HYPERTENSION
fascicolo: 7, volume: 12, anno: 1999,
pagine: 732 - 738
SICI:
0895-7061(199907)12:7<732:ASCWVI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURVIVAL;
Keywords:
spontaneously hypertensive rats; calcium entry blockers; pulse pressure; arterial remodeling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Safar, ME Hop Broussais, Dept Internal Med, 96 Rue Didot, F-75674 Paris 14, France Hop Broussais 96 Rue Didot Paris France 14 674 Paris 14, France
Citazione:
I. Koffi et al., "Arterial structural changes with verapamil in spontaneously hypertensive rats", AM J HYPERT, 12(7), 1999, pp. 732-738

Abstract

Reducing pulse pressure might be more powerful than reducing mean arterialpressure to obtain regression of vascular hypertrophy. However, this hypothesis has never been investigated in the conduit arteries of intact hypertensive animals. A group of 4-week-old spontaneously hypertensive rats (SHR) was treated with the calcium-entry blocker verapamil (50 mg/kg) for 16 weeks and compared with untreated SHR and control Wistar Kyoto (WKY) normotensive rats of the same age. At the end of the experiment, intraarterial thoracic aorta blood pressure was measured both in the conscious and anesthetizedanimals. Carotid artery diameter and stiffness (echo-tracking techniques) and aortic histomorphometry were determined in parallel. With verapamil, pulse pressure, but not mean arterial pressure, was significantly decreased but did not reach the normotensive values. Carotid internal diameter, medialthickness, and collagen content were significantly reduced by comparison with SHR and did not differ from the values of the WKY group. A significant positive and independent correlation was observed between pulse pressure and medial thickness in the overall population. The study shows that, in SHR chronically treated with verapamil, structural changes may be completely prevented without any change in mean arterial pressure. The parallel change in pulse pressure might suggest that mechanosensitive elements within the vascular wall may be selectively sensitive to the dynamic aspects of physicalforces and are able to convert frequency and amplitude information into cellular responses that lead to vascular remodeling. (C) 1999 American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 11:32:04