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Titolo:
Multiple previous alcohol detoxifications are associated with decreased medial temporal and paralimbic function in the postwithdrawal period
Autore:
George, MS; Teneback, CC; Malcolm, RJ; Moore, J; Stallings, LE; Spicer, KM; Anton, RF; Ballenger, JC;
Indirizzi:
Med Univ S Carolina, Dept Radiol, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 iol, Charleston, SC 29425 USA Med Univ S Carolina, Dept Neurol, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 rol, Charleston, SC 29425 USA MedSAniv S Carolina, Dept Psychiat, Alcohol Res Ctr, Charleston, SC 29425 U Med Univ S Carolina Charleston SC USA 29425 s Ctr, Charleston, SC 29425 U Ralph H Johnson VA Med Ctr, Dept Psychiat, Charleston, SC USA Ralph H Johnson VA Med Ctr Charleston SC USA sychiat, Charleston, SC USA
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 6, volume: 23, anno: 1999,
pagine: 1077 - 1084
SICI:
0145-6008(199906)23:6<1077:MPADAA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; ETHANOL WITHDRAWAL; KINDLING HYPOTHESIS; SEIZURES; EPISODES; SMOKING; BRAIN; CONSUMPTION; METABOLISM; NICOTINE;
Keywords:
alcoholism; detoxification; sensitization; imaging; medial temporal lobes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: George, MS Med Univ S Carolina, Dept Radiol, 171 Ashley Ave, Charleston, SC 29425 USA Med Univ S Carolina 171 Ashley Ave Charleston SC USA 29425 USA
Citazione:
M.S. George et al., "Multiple previous alcohol detoxifications are associated with decreased medial temporal and paralimbic function in the postwithdrawal period", ALC CLIN EX, 23(6), 1999, pp. 1077-1084

Abstract

Background: Functional neuroimaging studies after alcohol cessation have demonstrated that chronic alcohol use globally reduces neuronal activity forseveral weeks. Less is known about the effects of previous alcohol use patterns on regional brain activity. Multiple previous alcohol detoxificationsare associated with a worse clinical course and increased risk of seizures, perhaps due to sensitization of key brain structures. We performed the following imaging study in alcoholics in the postwithdrawal period to determine if blood now in medial temporal structures would differ as a function ofprevious alcohol use (i.e., whether regions were kindled or sensitized dueto multiple detoxifications). Methods: Fourteen adults meeting DSM-IV criteria for alcohol dependence (mean age 35, 8 SD; 10 men) and participating in a double-blind detoxification medication study underwent a brain perfusion Tc99 m-ECD (Neurolite) single photon emission computed tomography scan on days 7 through 9 (mean 7.6, .5 SD) after their last drink and 2 to 3 days since their last detoxification medication. Seven nonpsychiatrically ill, nonalcohol-dependent healthy adults were scanned as control subjects. Results: Alcoholics compared with controls had widely reduced relative activity in cortical secondary association areas and relatively increased activity in the medial temporal lobes (p < 0.01). Five alcoholic patients with greater than or equal to 2 previous detoxifications were compared with fivepatients in their first detoxification (age and detoxification medication matched). Multiple detoxification patients had significantly lower relativeactivity in bilateral anterior temporal poles and medial temporal lobes and in visual cortex (p < 0.01) compared with first episode patients. Conclusions: These studies are consistent with other studies comparing alcoholics and controls. They also suggest that on day 7 of detoxification, alcoholic subjects with multiple previous detoxifications have decreased visual cortex, medial temporal lobes, and anterior paralimbic blood flow, compared with those in their first detoxification. Further studies seem warranted to confirm these initial exploratory results.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:23:12