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Titolo:
Action of ethanol on responses to nicotine from cerebellar interneurons and medial septal neurons: Relationship to methyllycaconitine inhibition of nicotine responses
Autore:
Yang, YH; Criswell, HE; Breese, GR;
Indirizzi:
Univ N Carolina, Sch Med, Ctr Neurosci, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 rosci, Chapel Hill, NC 27599 USA Univ99 Carolina, Sch Med, Ctr Neurosci, Dept Pharmacol, Chapel Hill, NC 275 Univ N Carolina Chapel Hill NC USA 27599 t Pharmacol, Chapel Hill, NC 275 Univ N Carolina, Sch Med, Ctr Alcohol Studies, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 udies, Chapel Hill, NC 27599 USA Univ9N Carolina, Sch Med, Dept Psychiat & Anesthesiol, Chapel Hill, NC 2759 Univ N Carolina Chapel Hill NC USA 27599 nesthesiol, Chapel Hill, NC 2759
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 6, volume: 23, anno: 1999,
pagine: 983 - 990
SICI:
0145-6008(199906)23:6<983:AOEORT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BUNGAROTOXIN BINDING-SITES; SHORT-SLEEP MICE; CENTRAL-NERVOUS-SYSTEM; GATED ION CHANNELS; ACETYLCHOLINE-RECEPTOR; ALPHA-BUNGAROTOXIN; CROSS-TOLERANCE; LONG-SLEEP; LOCOMOTOR-ACTIVITY; RAT;
Keywords:
medial septal neurons; nicotine; ethanol; cerebellar interneurons; methyllycaconitine inhibition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Breese, GR Univ N Carolina, Sch Med, Ctr Neurosci, CB 7178, Chapel Hill, NC 27599 USA Univ N Carolina CB 7178 Chapel Hill NC USA 27599 , NC 27599 USA
Citazione:
Y.H. Yang et al., "Action of ethanol on responses to nicotine from cerebellar interneurons and medial septal neurons: Relationship to methyllycaconitine inhibition of nicotine responses", ALC CLIN EX, 23(6), 1999, pp. 983-990

Abstract

Background: A majority of alcoholics also smoke, suggesting that alcohol and nicotine share a common action on nicotinic cholinergic receptors. Methods: Extracellular single-unit recording was used to investigate the effects of ethanol on responses to nicotine from rat cerebellar interneuronsand medial septal neurons. Results: Nicotine produced inhibition from medial septal neurons, but increased neural activity of cerebellar interneurons. When ethanol was applied locally to cerebellar interneurons, the excitatory response to nicotine wasenhanced in a dose-related manner. Nicotine-induced inhibition from medialseptal neurons was reduced by ethanol from the majority of neurons, but a dose relationship for this inhibition by ethanol was not observed. Ethanol affected responses to nicotine from over 90% of all neurons investigated atthese sites. Initially, it was established that the nicotinic antagonists,methyllycaconitine (MLA) and alpha-bungarotoxin, which affect a nicotinic cholinergic (nACh) receptor with an alpha 7 subunit, had similar actions onresponses to nicotine from individual medial septal cells and cerebellar interneurons. When MLA was tested against responses to nicotine from neuronsin the two brain regions, MLA antagonized responses to nicotine from only 27% of the neurons rather than the 90% found for ethanol. This latter observation provided evidence that ethanol was affecting neurons with MLA-insensitive receptors. When the actions of ethanol on responses to nicotine were compared directly with the action of MLA on the same medial septal neurons,both ethanol and MLA caused a greater than 50% antagonism of the response to nicotine, indicative that nACh receptors with the alpha 7 subunit were sensitive to ethanol. Conclusions: Collectively, these data provide evidence that ethanol affects responses to nicotine not only from nACh receptors on medial septal cellsand cerebellar interneurons containing an alpha 7 subunit (i.e., MLA-sensitive receptors), but also from nACh receptor subtypes without this specificnACh receptor subunit (i.e., MLA-insensitive receptors).

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Documento generato il 18/09/20 alle ore 19:45:20