Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Colonic enteric nervous system in patients with familial amyloidotic neuropathy
Autore:
Anan, I; El-Salhy, M; Ando, Y; Forsgren, S; Nyhlin, N; Terazaki, H; Sakashita, N; Suhr, OB;
Indirizzi:
Umea Univ Hosp, Dept Med, Gastroenterol Sect, S-90185 Umea, Sweden Umea Univ Hosp Umea Sweden S-90185 troenterol Sect, S-90185 Umea, Sweden Umea Univ, S-90185 Umea, Sweden Umea Univ Umea Sweden S-90185Umea Univ, S-90185 Umea, Sweden Umea Univ Hosp, Dept Anat, S-90185 Umea, Sweden Umea Univ Hosp Umea Sweden S-90185 Hosp, Dept Anat, S-90185 Umea, Sweden Kumamoto Univ, Sch Med, Dept Internal Med 1, Kumamoto 860, Japan Kumamoto Univ Kumamoto Japan 860 ept Internal Med 1, Kumamoto 860, Japan Kumamoto Univ, Sch Med, Dept Pathol 2, Kumamoto 860, Japan Kumamoto Univ Kumamoto Japan 860 Med, Dept Pathol 2, Kumamoto 860, Japan
Titolo Testata:
ACTA NEUROPATHOLOGICA
fascicolo: 1, volume: 98, anno: 1999,
pagine: 48 - 54
SICI:
0001-6322(199907)98:1<48:CENSIP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUODENAL ENDOCRINE-CELLS; NITRIC-OXIDE; PRE-ALBUMIN; POLYNEUROPATHY; DYSFUNCTION;
Keywords:
familial amyloidotic polyneuropathy; protein gene product 9.5; vasoactive intestinal polypeptide; nitric oxide synthase; substance P; amyloid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Suhr, OB Umea Univ Hosp, Dept Med, Gastroenterol Sect, S-90185 Umea, Sweden Umea Univ Hosp Umea Sweden S-90185 l Sect, S-90185 Umea, Sweden
Citazione:
I. Anan et al., "Colonic enteric nervous system in patients with familial amyloidotic neuropathy", ACT NEUROP, 98(1), 1999, pp. 48-54

Abstract

The colonic enteric nervous system was investigated in autopsy specimens from 12 patients with familial amyloidotic neuropathy (FAP) and 9 controls. The infiltration of amyloid deposits in the enteric nervous system was studied by double staining for amyloid and nerve elements. The myenteric plexuswas immunostained for protein gene product (PGP) 9.5, vasoactive intestinal peptide (VIP), substance P and nitric oxide synthase (NOS). The immunostained nerve elements were quantified by computerised image analysis. Double staining revealed that there was no amyloid infiltration in the ganglia, orin the nerve fibres in the colonic enteric nervous system of FAP patients. The relative volume density of PGP 9.5-immunoreactive nerve fibres in boththe circular and the longitudinal muscle layers in FAP patients did not differ significantly from that of controls. The relative volume density of VIP-immunoreactive nerve fibres in the circular muscle layer was significantly decreased in FAP patients compared with controls, but not in the longitudinal layer. The number of VIP-immunoreactive neurons/mm(2) myenteric ganglia was significantly decreased in FAP patients. There were no statistical differences in the relative volume density for substance P- and NOS-immunoreactive nerve fibres between FAP patients and controls, nor was there any difference between FAP patients and controls regarding the number of NOS- and substance P-immunoreactive neurons/mm2 myenteric ganglia. It is concluded that the colonic enteric nervous system as a whole is intact and is not damaged by amyloid infiltration. The present observation of a reduction of VIP-immunoreactive nerve fibres and neurons in myenteric plexus of FAP patientsmight be one of the factors that contribute to the motility disorders seenin FAP patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:30:27