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Titolo:
NMSP binding to dopamine and serotonin receptors in MPTP-induced parkinsonism: relation to dopa therapy
Autore:
Borbely, K; Brooks, RA; Wong, DF; Burns, RS; Cumming, P; Gjedde, A; Di Chiro, G;
Indirizzi:
Aarhus Univ Hosp, PET Ctr, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp Aarhus Denmark C sp, PET Ctr, DK-8000 Aarhus C, Denmark NINDS, Neuroimaging Branch, NIH, Bethesda, MD 20892 USA NINDS Bethesda MDUSA 20892 roimaging Branch, NIH, Bethesda, MD 20892 USA NINDS, Clin Neurosci Branch, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 Neurosci Branch, NIH, Bethesda, MD 20892 USA Johns Hopkins Med Inst, Dept Radiol, Baltimore, MD 21287 USA Johns HopkinsMed Inst Baltimore MD USA 21287 ol, Baltimore, MD 21287 USA
Titolo Testata:
ACTA NEUROLOGICA SCANDINAVICA
fascicolo: 1, volume: 100, anno: 1999,
pagine: 42 - 52
SICI:
0001-6314(199907)100:1<42:NBTDAS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; LIVING HUMAN-BRAIN; C-11 RACLOPRIDE; RAT STRIATUM; DISEASE; PET; DENSITY; SCHIZOPHRENICS; QUANTIFICATION; NEURORECEPTORS;
Keywords:
dopamine; L-dihydroxyphenylalanine (L-dopa); Hoehn-&-Yahr staging; N-methyl-phenyl-tetrahydio-pyridine (MPTP); N-methylspiperone (NMSP) binding; parkinsonism; positron emission tomography (PET);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Gjedde, A Aarhus Univ Hosp, PET Ctr, 44 Norrebrogade, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp 44 Norrebrogade Aarhus Denmark C us C, Denmark
Citazione:
K. Borbely et al., "NMSP binding to dopamine and serotonin receptors in MPTP-induced parkinsonism: relation to dopa therapy", ACT NEUR SC, 100(1), 1999, pp. 42-52

Abstract

We tested the hypothesis that N-methylspiperone binding to dopamine D-2 receptors must be reduced when L-dopa therapy of parkinsonism augments the binding of dopamine to the receptors and improves the clinical state expressed by the Hoehn & Yahr stage. A patient with MPTP-induced parkinsonism underwent two positron emission tomographic studies of the D-2-like dopamine receptors with N-[C-11]methylspiperone (NMSP), The first study took place 3 days after cessation of the L-dopa medication, the second 5 days after its resumption. Noticeable clinical deterioration occurred during both studies, consistent with significant dopamine receptor blockade by NMSP and elevated NMSP binding in both scans. The dopa treatment. did not reduce the NMSP binding. On the contrary, the rate of binding of NMSP (k(3)) was increased on-dopa, compared to off-dopa. The increase was consistent with the slightly greater dopamine receptor density estimated after resumption of the dopa therapy. The NMSP binding to serotonin receptors suggested lower synaptic serotonin on-dopa than off-dopa. The results are consistent with negative correlation between the Hoehn & Yahr stage and the amount of dopamine bound to dopamine D-2 receptors. Low synaptic serotonin may explain the depression seen in some patients on dopa for Parkinson's disease.

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Documento generato il 25/01/20 alle ore 19:25:47