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Titolo:
Induction of arylhydrocarbon receptor expression in embryoblast cells of rabbit preimplantation blastocysts upon degeneration of Rauber's polar trophoblast
Autore:
Tscheudschilsuren, G; Kuchenhoff, A; Klonisch, T; Tetens, F; Fischer, B;
Indirizzi:
Univnyalle Wittenberg, Fac Med, Dept Anat & Cell Biol, D-06097 Halle, Germa Univ Halle Wittenberg Halle Germany D-06097 l Biol, D-06097 Halle, Germa
Titolo Testata:
TOXICOLOGY AND APPLIED PHARMACOLOGY
fascicolo: 2, volume: 157, anno: 1999,
pagine: 125 - 133
SICI:
0041-008X(19990601)157:2<125:IOAREI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARYL-HYDROCARBON RECEPTOR; HEAT-SHOCK PROTEIN; DIOXIN-RESPONSIVE ENHANCER; PROSTAGLANDIN-H SYNTHASE; TRANSFORMED AH-RECEPTOR; IN-VITRO FERTILIZATION; C57BL/6N MOUSE EMBRYO; NUCLEAR TRANSLOCATOR; DEVELOPMENTAL EXPRESSION; TRANSCRIPTION FACTORS;
Keywords:
arylhydrocarbon receptor (AhR); AhR nuclear translocator (ARNT); rabbit; preimplantation embryos; Rauber's polar trophoblast;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Tscheudschilsuren, G Univnyalle Wittenberg, Fac Med, Dept Anat & Cell Biol, D-06097 Halle, Germa Univ Halle Wittenberg Halle Germany D-06097 , Germa
Citazione:
G. Tscheudschilsuren et al., "Induction of arylhydrocarbon receptor expression in embryoblast cells of rabbit preimplantation blastocysts upon degeneration of Rauber's polar trophoblast", TOX APPL PH, 157(2), 1999, pp. 125-133

Abstract

The arylhydrocarbon receptor (AhR) is a ligand-activated transcription factor and mediates carcinogenic, teratogenic, and toxic effects of xenobiotics such as dioxin and coplanar polychlorinated biphenyls. The AhR nuclear translocator (ARNT) is involved in AhR signal transduction. We have analyzed the expression of AhR and ARNT mRNA and AhR protein in Day 3 pc (postcoitum) rabbit morulae and Days 4 and 6 pc blastocysts using RT-PCR, nested PCR, whole mount in situ hybridization, and whole mount immunohistochemistry with subsequent confocal laser scanning analysis. AhR and ARNT transcripts were detected in all stages investigated, indicating coexpression of both transcription factors. AhR protein was localized in the cytoplasm. It was detected in Day 3 pc morulae and in blastocysts. In Day 4 pc blastocysts, only trophoblast cells but not embryoblast cells were immunopositive. However, atDay 6 pc, the embryoblast cells also expressed AhR protein and this expression was correlated with the degeneration of Rauber's trophoblast layer. (C) 1999 Academic Press.

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Documento generato il 25/11/20 alle ore 06:55:24