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Titolo:
Bio-rational design of photosystem II inhibitors (VIII) - Molecular designsynthesis and inhibitory activity of acrylates (acrylamides)
Autore:
Liu, HY; Sha, YL; Tan, HF; Yang, HZ; Lai, LH;
Indirizzi:
Nankai Univ, State Key Lab, Tianjin 300071, Peoples R China Nankai Univ Tianjin Peoples R China 300071 anjin 300071, Peoples R China Nankai Univ, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China Nankai Univ Tianjin Peoples R China 300071 anjin 300071, Peoples R China Peking1,niv, Inst Phys Chem, Natl State & Unstate Struct Lab, Beijing 10087 Peking Univ Beijing Peoples R China 100871 ate Struct Lab, Beijing 10087
Titolo Testata:
SCIENCE IN CHINA SERIES B-CHEMISTRY
fascicolo: 3, volume: 42, anno: 1999,
pagine: 326 - 331
SICI:
1001-652X(199906)42:3<326:BDOPII>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Keywords:
photosystem II; acrylates (acrylamides); molecular modeling; molecular design; Hill reaction inhibitory activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, HZ Nankai Univ, State Key Lab, Tianjin 300071, Peoples R China Nankai Univ Tianjin Peoples R China 300071 071, Peoples R China
Citazione:
H.Y. Liu et al., "Bio-rational design of photosystem II inhibitors (VIII) - Molecular designsynthesis and inhibitory activity of acrylates (acrylamides)", SCI CHINA B, 42(3), 1999, pp. 326-331

Abstract

Molecular modeling of acrylates (acrylamides) with D1 protein of Pisum sativum is presented. Studies show that the binding force mainly includes H-bond interaction, Van der Waals and x-ring stacking interaction. It was foundthat SER 268 in D1 protein might he an important binding site. It is important for high inhibitory activity of compounds whether an electronegative atom in alkyl of ester linkage could make H-bond interaction with SER 268 inD1 protein. Thus some new acrylates (acrylamides) were designed and synthesized. Bioassay indicated that these new compounds showed expected Hill reaction inhibitory activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 11:15:56