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Titolo:
Comparison of set-shifting ability in patients with chronic schizophrenia and frontal lobe damage
Autore:
Pantelis, C; Barber, FZ; Barnes, TRE; Nelson, HE; Owen, AM; Robbins, TW;
Indirizzi:
UnivcMelbourne, Dept Psychiat, Cognit Neuropsychiat Res Unit, Parkville, Vi Univ Melbourne Parkville Vic Australia 3052 chiat Res Unit, Parkville, Vi Mental Hlth Res Inst, Appl Schizophrenia Div, Parkville, Vic, Australia Mental Hlth Res Inst Parkville Vic Australia , Parkville, Vic, Australia UnivlLondon Imperial Coll Sci Technol & Med, Sch Med, Div Neurosci & Psycho Univ London Imperial Coll Sci Technol & Med London England sci & Psycho Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England Univ Cambridge Cambridge England CB2 3EB hol, Cambridge CB2 3EB, England
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 3, volume: 37, anno: 1999,
pagine: 251 - 270
SICI:
0920-9964(19990622)37:3<251:COSAIP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARD SORTING TEST; CEREBRAL BLOOD-FLOW; DORSOLATERAL PREFRONTAL CORTEX; STRIATAL COGNITIVE DEFICITS; FIRST-EPISODE SCHIZOPHRENIA; PARKINSONS-DISEASE; HUNTINGTONS-DISEASE; NEUROPSYCHOLOGICAL DEFICITS; FRONTOSTRIATAL DYSFUNCTION; EXECUTIVE FUNCTION;
Keywords:
frontal-striatal; IQ; learning; neuropsychology; schizophrenia; set-shifting; symptoms;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Pantelis, C UnivcMelbourne, Dept Psychiat, Cognit Neuropsychiat Res Unit, Parkville, Vi Univ Melbourne Parkville Vic Australia 3052 it, Parkville, Vi
Citazione:
C. Pantelis et al., "Comparison of set-shifting ability in patients with chronic schizophrenia and frontal lobe damage", SCHIZOPHR R, 37(3), 1999, pp. 251-270

Abstract

Neuropsychological studies of patients with schizophrenia have consistently identified deficits on tests sensitive to frontal lobe function. One paradigm that has been widely used is that of attentional set-shifting using the Wisconsin Card Sorting Test (WCST). In the present study, patients with chronic schizophrenia and with frontal lobe lesions were assessed on a computerised set-shifting task that provides a componential analysis of the WCSTby distinguishing between intra-dimensional and extra-dimensional set-shifting. Out of 51 patients with schizophrenia, those with high IQ (n=24) werecompared with patients with lesions in prefrontal cortex (n=22) and with normal control subjects (n=18). These three groups were well matched for age, sex and National Adult Reading Test (NART) IQ. The schizophrenic group showed a significantly higher rate of attrition at the intra-dimensional shift stage of learning compared with the other two groups. At the extra-dimensional shift stage, both the schizophrenic and frontal lesioned groups showed greater attrition than controls. Further, patients with schizophrenia whowere able to learn the intradimensional reversal stage required more trials and made significantly more errors at that stage than the other two groups. In comparison with high IQ patients with schizophrenia, those with low IQ performed at a lower level but showed a qualitatively similar pattern of performance, providing further evidence that the set-shifting deficits werenot simply explained by any global intellectual decline. Patients with schizophrenia who dropped out at the extra-dimensional shift stage had higher negative symptom scores compared with patients dropping out at previous learning stages, while patients failing at the intra-dimensional shift stage had lower scores for bradyphrenia (slowness of thought). The results suggestthat patients with chronic schizophrenia fail to 'learn set' and are impaired at both set-shifting and concept formation. The relevance of these findings to understanding the nature of prefrontal cortical deficits in chronicschizophrenia is discussed. The implication of these findings to the rehabilitation of these patients is considered. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 05/04/20 alle ore 04:11:49