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Titolo:
LIMB LENGTHENING PROMOTES MUSCLE GROWTH
Autore:
DAY CS; MORELAND MS; FLOYD SS; HUARD J;
Indirizzi:
CHILDRENS HOSP PITTSBURGH,MUSCULOSKELETAL RES CTR,DEPT ORTHOPAED SURGPITTSBURGH PA 15261 CHILDRENS HOSP PITTSBURGH,MUSCULOSKELETAL RES CTR,DEPT ORTHOPAED SURGPITTSBURGH PA 15261 UNIV PITTSBURGH PITTSBURGH PA 00000
Titolo Testata:
Journal of orthopaedic research
fascicolo: 2, volume: 15, anno: 1997,
pagine: 227 - 234
SICI:
0736-0266(1997)15:2<227:LLPMG>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE; REGENERATION; DISTRACTION; MYOGENESIS; INVITRO; RABBITS; DESMIN; NUCLEI; LIGHT; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
C.S. Day et al., "LIMB LENGTHENING PROMOTES MUSCLE GROWTH", Journal of orthopaedic research, 15(2), 1997, pp. 227-234

Abstract

Studies of limb lengthening have demonstrated successful bone formation in the distraction gap. Failure of the muscle units to lengthen leads to many complications that significantly limit the success of this approach; it is, therefore, of paramount importance to characterize the behavior of the muscle during limb lengthening. In this study, tibiae of adult rabbits were lengthened for 10 days at a rate of 1 mm/day. The proliferative ability of the lengthened muscle was characterized using bromodeoxyuridine, a thymidine analogue that is incorporated during cell division, and desmin, a muscle-specific marker. We observed a large number of proliferating cells, specifically in the lengthened muscle, that were co-localized with many desmin-positive cells. The presence of bromodeoxyuridine nuclei inside desmin-positive muscle fibers suggests that limb lengthening promotes muscle growth by triggering myoblast proliferation and fusion into the lengthened muscle. Our findings are consistent with those of other studies in the reviewed literature that also suggest that limb lengthening promotes muscle growth.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 03:02:24