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Titolo:
Quantitative proton magnetic resonance spectroscopy of the bilateral frontal lobes in patients with bipolar disorder
Autore:
Hamakawa, H; Kato, T; Shioiri, T; Inubushi, T; Kato, N;
Indirizzi:
Shiga Univ Med Sci, Dept Psychiat, Otsu, Shiga 52021, Japan Shiga Univ MedSci Otsu Shiga Japan 52021 chiat, Otsu, Shiga 52021, Japan Shiga Univ Med Sci, Mol Neurobiol Res Ctr, Otsu, Shiga 52021, Japan Shiga Univ Med Sci Otsu Shiga Japan 52021 s Ctr, Otsu, Shiga 52021, Japan Univ Tokyo, Fac Med, Dept Neuropsychiat, Tokyo 113, Japan Univ Tokyo Tokyo Japan 113 Fac Med, Dept Neuropsychiat, Tokyo 113, Japan
Titolo Testata:
PSYCHOLOGICAL MEDICINE
fascicolo: 3, volume: 29, anno: 1999,
pagine: 639 - 644
SICI:
0033-2917(199905)29:3<639:QPMRSO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN ENERGY-METABOLISM; BASAL GANGLIA; CREATINE; PHOSPHOCREATINE; DEPRESSION; SPECTRA; INVIVO; CSF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Hamakawa, H Shigapaniv Med Sci, Dept Psychiat, Seta Tsukinowacho, Otsu, Shiga 52021, Ja Shiga Univ Med Sci Seta Tsukinowacho Otsu Shiga Japan 52021 Ja
Citazione:
H. Hamakawa et al., "Quantitative proton magnetic resonance spectroscopy of the bilateral frontal lobes in patients with bipolar disorder", PSYCHOL MED, 29(3), 1999, pp. 639-644

Abstract

Background. Using P-31 and H-1 magnetic resonance spectroscopy (MRS) we previously reported that phosphocreatine was decreased in the left frontal lobe and choline-containing compounds were increased in the basal ganglia in the depressive state in patients with bipolar disorder. We applied quantitative H-1-MRS for further characterization of biochemical alteration in the frontal lobes of bipolar patients. Methods. Twenty-three bipolar patients and 20 normal controls were examined by H-1-MRS with a 1.5T MR system. All patients were examined in the euthymic state, and eight patients were also examined in the depressive state. Volumes of interest of 2.5 x 2.5 x 2.5 cm were selected in the left and right frontal lobes, Absolute concentrations of N-acetyl-1-aspartate, creatine plus phospho-creatine, and choline-containing compounds were calculated from each metabolite peak. Results. Creatine concentration in the left frontal lobe in bipolar patients in the depressive state was significantly lower than that in the euthymic state. Creatine concentration in the right frontal lobe in the male patients was significantly higher than that in the female patients and a similartrend was also found in the control subjects. Conclusions. We found a state-dependent change of creatine metabolism in the left frontal lobe of bipolar patients. The present results are compatible with our previous report of decreased phosphocreatine measured by P-31-MRS in the left frontal lobe in bipolar disorder. We also found an effect of gender on the creatine concentration. There may be a gender difference in creatine transport function into the brain.

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Documento generato il 25/01/20 alle ore 18:36:15