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Titolo:
Protein phosphorylation and signal transduction
Autore:
Graves, JD; Krebs, EG;
Indirizzi:
Univ Washington, Dept Immunol, Med Ctr, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 unol, Med Ctr, Seattle, WA 98195 USA Univ Washington, Dept Pharmacol, Med Ctr, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 acol, Med Ctr, Seattle, WA 98195 USA
Titolo Testata:
PHARMACOLOGY & THERAPEUTICS
fascicolo: 2-3, volume: 82, anno: 1999,
pagine: 111 - 121
SICI:
0163-7258(199905/06)82:2-3<111:PPAST>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CASPASE-MEDIATED ACTIVATION; ICE/CED-3 FAMILY PROTEASES; PROGRAMMED CELL-DEATH; MAP KINASE; INDUCED APOPTOSIS; ICE-LIKE; POLY(ADP-RIBOSE) POLYMERASE; MAMMALIAN-CELLS; UV-LIGHT; LAMIN-A;
Keywords:
protein kinases; second messengers; inhibitors; apoptosis; caspases; MAPKs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Krebs, EG Univ Washington, Dept Immunol, Med Ctr, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Ctr, Seattle, WA 98195 USA
Citazione:
J.D. Graves e E.G. Krebs, "Protein phosphorylation and signal transduction", PHARM THERA, 82(2-3), 1999, pp. 111-121

Abstract

It is now generally accepted that protein phosphorylation-dephosphorylation has a role in the regulation of essentially all cellular functions. Thus,it is of interest that this process is involved in signal transduction. Nonetheless, the extent to which protein phosphorylation participates in signaling is truly remarkable. Almost every known signaling pathway eventually impinges on a protein kinase, or in some instances, a protein phosphatase. The diversity of these enzymes is noteworthy, and it is of interest that many biotechnology companies are eyeing them as potentially important targetsfor drugs. Such drugs may have important therapeutic applications, and in any event, they certainly will be useful to investigators who study signal transduction. Indeed, this already has been proven to be true. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:24:24