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Titolo:
The NM23 gene and its expression in oral squamous cell carcinoma
Autore:
Lo Muzio, L; Mignogna, MD; Pannone, G; Staibano, S; Procaccini, M; Serpico, R; de Rosa, G; Scully, C;
Indirizzi:
Univ Naples Federico II, Fac Med, Div Oral Med & Pathol, Naples, Italy Univ Naples Federico II Naples Italy v Oral Med & Pathol, Naples, Italy Univ Naples Federico II, Fac Med, Dept Biomorphol & Funct Sci, Pathol Unit, Univ Naples Federico II Naples Italy omorphol & Funct Sci, Pathol Unit, Univ Ancona, Fac Med, Inst Dent Sci, Ancona, Italy Univ Ancona Ancona Italy Ancona, Fac Med, Inst Dent Sci, Ancona, Italy Univ Bari, Inst Dent & Maxillofacial Surg, Bari, Italy Univ Bari Bari Italy Bari, Inst Dent & Maxillofacial Surg, Bari, Italy Univ London, Eastman Dent Inst Oral Hlth Care Sci, London WC1E 7HU, England Univ London London England WC1E 7HU h Care Sci, London WC1E 7HU, England
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 4, volume: 6, anno: 1999,
pagine: 747 - 751
SICI:
1021-335X(199907/08)6:4<747:TNGAIE>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOSIDE DIPHOSPHATE KINASE; HUMAN BREAST-CANCER; LYMPH-NODE INVOLVEMENT; INVERSE CORRELATION; TUMOR PROGRESSION; IMMUNOHISTOCHEMICAL ANALYSIS; REDUCED EXPRESSION; GOOD PROGNOSIS; RNA LEVELS; METASTASIS;
Keywords:
oral cavity; squamous cell carcinoma; metastasis; NM23; NM23-H1; NM23-H2; nucleoside diphosphate kinase; immunohistochemistry; skin melanoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Lo Muzio, L Via Carelli 28, I-71100 Foggia, Italy Via Carelli 28 Foggia Italy I-71100 8, I-71100 Foggia, Italy
Citazione:
L. Lo Muzio et al., "The NM23 gene and its expression in oral squamous cell carcinoma", ONCOL REP, 6(4), 1999, pp. 747-751

Abstract

The murine nm23, a putative metastasis suppressor, has three human homologues, NM23-H1, -H2, and -H3b. Several reports have suggested a low metastatic potential for neoplasms with a high expression of NM23-H1 gene, while other studies have not shown this relationship. These apparent differences in the role of NM23 in metastasis suppression might be explained by unability to discriminate between the expression of the two genes NM23-H1 and NM23-H2. The NM23-H2 product is not related to tumor progression and metastasis suppression. Two studies on human oral squamous cell carcinoma (OSCC) have been reported, both showing the NM23 product to be a metastasis suppressor factor. However, none of these two studies distinguished NM23-H1 from NM23-H2. The aim of this study was to detect the protein expression pattern of NM23-H1 product in 24 OSCCs by immunohistochemistry in paraffin-embedded tissues using a monoclonal antibody non-cross-reactive with NM23-H2. The NM23-H1positive group showed lower frequency of lymph node metastasis, and a better grading than the NM23-H1 negative group supporting the role of NM23-H1 as metastasis suppressor factor which may be useful for predicting tumor metastasis in OSCC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 02:20:47