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Titolo:
POSTOPERATIVE NEUROPSYCHOLOGICAL DYSFUNCTION AND CEREBRAL OXYGENATIONDURING CARDIAC-SURGERY
Autore:
NOLLERT G; MOHNLE P; TASSANIPRELL P; UTTNER I; BORASIO GD; SCHMOECKEL M; REICHART B;
Indirizzi:
KLINIKUM GROSSHADERN,MARCHIONINISTR 15 D-81366 MUNICH GERMANY UNIV MUNICH,INST ANESTHESIOL,DEPT CARDIAC SURG MUNICH GERMANY UNIV MUNICH,DEPT NEUROL W-8000 MUNICH GERMANY
Titolo Testata:
The thoracic and cardiovascular surgeon
fascicolo: 5, volume: 43, anno: 1995,
pagine: 260 - 264
SICI:
0171-6425(1995)43:5<260:PNDACO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOPULMONARY BYPASS; BRAIN; METABOLISM; SUFFICIENCY; PERFUSION; ISCHEMIA; TISSUE;
Keywords:
HEART SURGERY; NEUROPSYCHOLOGICAL COMPLICATIONS; CEREBRAL OXYGENATION; NEAR INFRARED SPECTROSCOPY; EXTRACORPOREAL CIRCULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
G. Nollert et al., "POSTOPERATIVE NEUROPSYCHOLOGICAL DYSFUNCTION AND CEREBRAL OXYGENATIONDURING CARDIAC-SURGERY", The thoracic and cardiovascular surgeon, 43(5), 1995, pp. 260-264

Abstract

In 41 patients undergoing cardiac operations with extracorporeal circulation, oxidized cytochrome a,a3 (CtO(2)), deoxygenated hemoglobin (Hb), and oxygenated hemoglobin (HbO(2)) were measured in brain tissue by near-infrared spectrophotometry (NIRS) intraoperatively. Monitoring also included electroencephalography (EEG) and jugular-bulb venous saturation (SBJO2). All operations were performed using membrane oxygenators, moderate hypothermia (26-28 degrees C) and pH alpha-stat management. During cardiopulmonary bypass (CPB) CtO(2) and HbO(2) were reduced, reaching minimal values when rewarming was instituted. At the end ofthe operation CtO(2) and HbO(2) had regained initial levels. During CPB, arterial PCO2, pH, and temperature were closely related to CtO(2) (r = 1000, r = -0.964 and 0.929 respectively; p < 0.001, p < 0.001, and p < 0.003 respectively). Neuropsychological testing by the Mini-Mental-State Test indicated reversible postoperative neuropsychologicai deficits in four patients. These patients had a lower CtO(2) minimum compared to those without these deficits (-4.5 mu mol/L v. -0.7 mu mol/L;p = 0.036). These findings support the hypothesis that neuropsychological deficits in patients after cardiac surgery can be caused by intraoperative cerebral hypoxia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:34:31