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Titolo:
Neuronal cell death during sexual differentiation and lateralisation of vocal communication (vol 22, pg 725, 1998)
Autore:
Holman, SD;
Indirizzi:
Univ Cambridge, Dept Anat, Cambridge CB2 3DY, England Univ Cambridge Cambridge England CB2 3DY nat, Cambridge CB2 3DY, England
Titolo Testata:
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
fascicolo: 5, volume: 23, anno: 1999,
pagine: 761 -
SICI:
0149-7634(199905)23:5<761:NCDDSD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-RIGHT ASYMMETRY; PREOPTIC AREA; DIMORPHIC AREA; GERBIL HYPOTHALAMUS; SCENT MARKING; DEVELOPMENTAL BIOLOGY; PATHOLOGICAL RESEARCH; FUNCTIONAL ASYMMETRY; MONGOLIAN GERBILS; BRAIN-FUNCTION;
Keywords:
lateral asymmetry; anterior hypothalamus; gerbil; sociosexual ultrasounds; stereology;
Tipo documento:
Correction, Addition
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Holman, SD Univ Cambridge, Dept Anat, Downing St, Cambridge CB2 3DY, England Univ Cambridge Downing St Cambridge England CB2 3DY Y, England
Citazione:
S.D. Holman, "Neuronal cell death during sexual differentiation and lateralisation of vocal communication (vol 22, pg 725, 1998)", NEUROSCI B, 23(5), 1999, pp. 761

Abstract

A rodent analogy has been established to investigate the neural mechanismsoccurring during sexual differentiation and lateralization. A sexually dimorphic hypothalamic nucleus (SDApc) is closely associated with a stereotyped, courtship vocalisation in male gerbils. Stereological analysis of SDApc cytoarchitecture reveals that neuron number and nuclear volume are asymmetric in male adults. Strikingly, neuron number on the left side of the SDApc correlates significantly with the rate of the courtship call in males. Exogenous testosterone treatment in female neonates masculinises and lateralises SDApc structure and function. Neuronal programmed cell death (apoptosis),manifested in SDApcs of neonates, is more frequent in females. Significantly, apoptosis in males is lateralised, as revealed by lateral asymmetry of neuron number at postnatal day 16. It is concluded that neuroendocrine-dependent, sexual differentiation and lateralization are concurrent and influenced by apoptotic mechanisms. It is suggested that apoptosis is the result of a genetically-driven device, inherent in postmitotic, undifferentiated cells which may have recently migrated into the SDApc. The genomic mechanism inducing lateralised apoptosis is apparently activated only neonatally in males. (C) 1998 Elsevier Science Ltd. All rights reversed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 04:57:09