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Titolo:
A double dissociation within the hippocampus of dopamine D-1/D-5 receptor and beta-adrenergic receptor contributions to the persistence of long-term potentiation
Autore:
Swanson-Park, JL; Coussens, CM; Mason-Parker, SE; Raymond, CR; Hargreaves, EL; Dragunow, M; Cohen, AS; Abraham, WC;
Indirizzi:
Univ Otago, Dept Psychol, Dunedin, New Zealand Univ Otago Dunedin New Zealand tago, Dept Psychol, Dunedin, New Zealand Univ Otago, Neurosci Res Ctr, Dunedin, New Zealand Univ Otago Dunedin New Zealand , Neurosci Res Ctr, Dunedin, New Zealand Univandckland, Sch Med, Dept Pharmacol & Clin Pharmacol, Auckland, New Zeal Univ Auckland Auckland New Zealand & Clin Pharmacol, Auckland, New Zeal
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 92, anno: 1999,
pagine: 485 - 497
SICI:
0306-4522(1999)92:2<485:ADDWTH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS COERULEUS NEURONS; DENTATE GYRUS; CA1 REGION; POPULATION SPIKE; AREA CA1; PYRAMIDAL NEURONS; RAT HIPPOCAMPUS; PERFORANT PATH; LATE-PHASE; LTP;
Keywords:
hippocampus; dentate gyrus; LTP; dopamine; noradrenaline; inducible transcription factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Abraham, WC Univ Otago, Dept Psychol, Box 56, Dunedin, New Zealand Univ Otago Box 56 Dunedin New Zealand , Dunedin, New Zealand
Citazione:
J.L. Swanson-Park et al., "A double dissociation within the hippocampus of dopamine D-1/D-5 receptor and beta-adrenergic receptor contributions to the persistence of long-term potentiation", NEUROSCIENC, 92(2), 1999, pp. 485-497

Abstract

We compared the effects of the D-1/D-5 receptor antagonist SCH-23390 with the beta-adrenergic receptor antagonist propranolol on the persistence of long-term potentiation in the CA1 and dentate gyrus subregions of the hippocampus. In slices, SCH-23390 but not propranolol reduced the persistence of longterm potentiation in area CA1 without affecting its induction. The drugs exerted reverse effects in the dentate gyrus, although in this case the induction of long-term potentiation was also affected by propranolol. The lack of effect of SCH-23390 on the induction and maintenance of long-term potentiation in the dentate gyrus was confirmed in awake animals. The drug also had little or no effect on the expression of inducible transcription factors. In area CA1 of awake animals, SCH-23390 blocked persistence of longterm potentiation beyond 3 h, confirming the results in slices. To rule our a differential release of catecholamines induced by our stimulation protocolsbetween brain areas, we compared the effects of the D-1/D-5 agonist SKF-38393 with the beta-adrenergic agonist isoproterenol on the persistence of a weakly induced, decremental long-term potentiation in CA1 slices. SKF-38393but not isoproterenol promoted greater persistence of long-term potentiation over a 2-h period. In contrast, isoproterenol but not SKF-38392 facilitated the: induction of long-term potentiation. These data demonstrate that there is a double dissociation of the catecholamine modulation of long-term potentiation between CA1 and the dentate gyrus, suggesting that long-term potentiation in these brain areas may be differentially consolidated according to the animal's behavioural state. (C) 1999 IBRO. published by Elsevier Science Ltd.

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Documento generato il 25/11/20 alle ore 15:31:17