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Titolo:
Neuroendocrine and psychophysiologic responses in PTSD: A symptom provocation study
Autore:
Liberzon, I; Abelson, JL; Flagel, SB; Raz, J; Young, EA;
Indirizzi:
Univ Michigan, Dept Psychiat PCT116A, Ann Arbor, MI 48105 USA Univ Michigan Ann Arbor MI USA 48105 iat PCT116A, Ann Arbor, MI 48105 USA Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48105 USA Univ Michigan Ann Arbor MI USA 48105 ept Biostat, Ann Arbor, MI 48105 USA VAMC, Psychiat Serv, Ann Arbor, MI USA VAMC Ann Arbor MI USAVAMC, Psychiat Serv, Ann Arbor, MI USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 21, anno: 1999,
pagine: 40 - 50
SICI:
0893-133X(199907)21:1<40:NAPRIP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTTRAUMATIC-STRESS-DISORDER; VIETNAM COMBAT VETERANS; CORTICOTROPIN-RELEASING HORMONE; CATECHOLAMINE EXCRETION; PLASMA NOREPINEPHRINE; CORTISOL EXCRETION; URINARY CORTISOL; MENTAL STRESS; RAT-BRAIN; IMAGERY;
Keywords:
stress; catecholamines; cortisol; corticotropin; skin conductance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Liberzon, I UnivSAichigan, Dept Psychiat PCT116A, 2215 Fuller Rd, Ann Arbor, MI 48105 U Univ Michigan 2215 Fuller Rd Ann Arbor MI USA 48105 MI 48105 U
Citazione:
I. Liberzon et al., "Neuroendocrine and psychophysiologic responses in PTSD: A symptom provocation study", NEUROPSYCH, 21(1), 1999, pp. 40-50

Abstract

Biological research oil post-traumatic stress disorder (PTSD) has focused on autonomic, sympatho-adrenal, and hypothalamo-pituitary-adrenal (HPA) axis systems. Interactions among these response modalities have not been well studied and may be illuminating. We examined subjective, automatic, adrenergic, and HPA axis responses ill a trauma-cue paradigm and explores the hypothesis that the ability of linked stress-response systems to mount integrated responses to environmental threat would produce strong correlations across systems. Seventeen veterans with PTSD, 11 veteran controls without PTSD,and 14 nonveteran controls were exposed to white noise and combat sounds on separate nays. Subjective distress, heart rate, skill conductance, plasmacatecholamines, ACTH, and cortisol, at baseline and in response to the auditory stimuli, were analyzed for group differences and for patterns of interrelationships. PTSD patients exhibited higher skin conductance, heart rate, plasma cortisol, and catecholamines at baselines, and exaggerated responses to combat sounds in skill conductance, heart rate, plasma epinephrine, and norepinephrine, but not ACTH. The control groups did not differ on any measure. In canonical control groups did not differ on any measure. In canonical between response systems. Thus, PTSD patients showed heightened reponsivity to trauma-related cues in some, but not all, response modalities. Thedata did not support the integrated, multisystem stress response in PTSD that had been hypothesized. Individual response differences or differing pathological processes may determine which neurobiological system is affected in any given patient. (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 30/03/20 alle ore 00:55:45