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Titolo:
Extracellular matrix proteins protect small cell lung cancer cells againstapoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo
Autore:
Sethi, T; Rintoul, RC; Moore, SM; MacKinnon, AC; Salter, D; Choo, C; Chilvers, ER; Dransfield, I; Donnelly, SC; Strieter, R; Haslett, C;
Indirizzi:
Univthian,urgh, Sch Med, Rayne Lab, Resp Med Unit, Edinburgh EH8 9AG, Midlo Univ Edinburgh Edinburgh Midlothian Scotland EH8 9AG burgh EH8 9AG, Midlo Univnddinburgh, Sch Med, Dept Pathol, Edinburgh EH8 9AG, Midlothian, Scotla Univ Edinburgh Edinburgh Midlothian Scotland EH8 9AG , Midlothian, Scotla Univ Michigan, Med Ctr, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 an, Med Ctr, Ann Arbor, MI 48109 USA
Titolo Testata:
NATURE MEDICINE
fascicolo: 6, volume: 5, anno: 1999,
pagine: 662 - 668
SICI:
1078-8956(199906)5:6<662:EMPPSC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE NEUROPEPTIDES; SURVIVAL FACTOR; FIBRONECTIN; INHIBITION; EXPRESSION; CARCINOMA; INTEGRIN; RECEPTOR; TENASCIN; ADHESION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Sethi, T Univ Edinburgh, Sch Med, Rayne Lab, Resp Med Unit, Teviot Pl, Edinburgh EH8 Univ Edinburgh Teviot Pl Edinburgh Midlothian Scotland EH8 9AG H8
Citazione:
T. Sethi et al., "Extracellular matrix proteins protect small cell lung cancer cells againstapoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo", NAT MED, 5(6), 1999, pp. 662-668

Abstract

Resistance to chemotherapy is a principal problem in the treatment of small cell lung cancer (SCLC). We show here that SCLC is surrounded by an extensive stroma of extracellular matrix (ECM) at both primary and metastatic sites. Adhesion of SCLC cells to ECM enhances tumorigenicity and confers resistance to chemotherapeutic agents as a result of pi integrin-stimulated tyrosine kinase activation suppressing chemotherapy-induced apoptosis. SCLC may create a specialized microenvironment, and the survival of cells bound toECM could explain the partial responses and local recurrence of SCLC oftenseen clinically after chemotherapy. Strategies based on blocking pi integrin-mediated survival signals may represent a new therapeutic approach to improve the response to chemotherapy in SCLC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:58:46