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Titolo:
Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat proteinvaccine
Autore:
Cafaro, A; Caputo, A; Fracasso, C; Maggiorella, MT; Goletti, D; Baroncelli, S; Pace, M; Sernicola, L; Koanga-Mogtomo, ML; Betti, M; Borsetti, A; Belli, R; Akerblom, L; Corrias, F; Butto, S; Heeney, J; Verani, P; Titti, F; Ensoli, B;
Indirizzi:
Ist Super Sanita, Virol Lab, I-00161 Rome, Italy Ist Super Sanita Rome Italy I-00161 nita, Virol Lab, I-00161 Rome, Italy Univ Ferrara, Dept Exp & Diagnost Med, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 Diagnost Med, I-44100 Ferrara, Italy Natl Vet Inst, Dept Virol, Biomed Ctr, S-75183 Uppsala, Sweden Natl Vet Inst Uppsala Sweden S-75183 Biomed Ctr, S-75183 Uppsala, Sweden Biomed Primate Res Ctr, Dept Virol, NL-2288 GJ Rijswijk ZH, Netherlands Biomed Primate Res Ctr Rijswijk Netherlands ZH Rijswijk ZH, Netherlands
Titolo Testata:
NATURE MEDICINE
fascicolo: 6, volume: 5, anno: 1999,
pagine: 643 - 650
SICI:
1078-8956(199906)5:6<643:COSOCM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CYTOTOXIC T-LYMPHOCYTES; TRANS-ACTIVATOR GENE; KAPOSIS-SARCOMA; ATTENUATED SIV; GROWTH-FACTOR; CELL-GROWTH; TNF-ALPHA; HTLV-III; NEF GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Ensoli, B Ist Super Sanita, Virol Lab, Viale Regina Elena 299, I-00161 Rome, Italy Ist Super Sanita Viale Regina Elena 299 Rome Italy I-00161 taly
Citazione:
A. Cafaro et al., "Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat proteinvaccine", NAT MED, 5(6), 1999, pp. 643-650

Abstract

Vaccine strategies aimed at blocking virus entry have so far failed to induce protection against heterologous viruses. Thus, the control of viral infection and the block of disease onset may represent a more achievable goal of human immunodeficiency virus (HIV) vaccine strategies. Here we show thatvaccination of cynomolgus monkeys with a biologically active HIV-1 Tat protein is safe, elicits a broad (humoral and cellular) specific immune response and reduces infection with the highly pathogenic simian-human immunodeficiency virus (SHIV)-89.6P to undetectable levels, preventing the CD4(+) T-cell decrease. These results may provide new opportunities for the development of a vaccine against AIDS.

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Documento generato il 02/12/20 alle ore 04:15:56