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Titolo:
Structural basis of G protein-coupled receptor function
Autore:
Schoneberg, T; Schultz, G; Gudermann, T;
Indirizzi:
Free Univ Berlin, Inst Pharmacol, D-14195 Berlin, Germany Free Univ Berlin Berlin Germany D-14195 armacol, D-14195 Berlin, Germany
Titolo Testata:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
fascicolo: 1-2, volume: 151, anno: 1999,
pagine: 181 - 193
SICI:
0303-7207(19990525)151:1-2<181:SBOGPR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEPHROGENIC DIABETES-INSIPIDUS; TRANSMEMBRANE ALPHA-HELICES; HUMAN LUTROPIN/CHORIOGONADOTROPIN RECEPTOR; CHORIONIC-GONADOTROPIN RECEPTOR; CONSTITUTIVELY ACTIVE MUTANTS; BETA(2) ADRENERGIC-RECEPTOR; HUMAN THYROTROPIN RECEPTOR; TACHYKININ NK-1 RECEPTOR; V2 VASOPRESSIN RECEPTORS; 2ND INTRACELLULAR LOOP;
Keywords:
multiple coupling; receptor assembly; trafficking; oligomerization;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
154
Recensione:
Indirizzi per estratti:
Indirizzo: Schoneberg, T Free Univ Berlin, Inst Pharmacol, Thielallee 69-73, D-14195 Berlin, Germany Free Univ Berlin Thielallee 69-73 Berlin Germany D-14195 ny
Citazione:
T. Schoneberg et al., "Structural basis of G protein-coupled receptor function", MOL C ENDOC, 151(1-2), 1999, pp. 181-193

Abstract

The vast majority of extracellular signaling molecules, like hormones and neurotransmitters, interact with a class of membranous receptors characterized by a uniform molecular architecture of seven transmembrane cr-helices linked by extra- and intracelluar peptide loops. In a reversible manner, binding of diverse agonists to heptahelical receptors leads to activation of alimited repertoire of heterotrimeric guanine nucleotide-binding proteins (G proteins) forwarding the signal to intracellular effecters such as enzymes and ion channels. Proper functioning of a G protein-coupled receptor is based on a complex interplay of structural determinants which are ultimatelyresponsible for receptor folding, trafficking and transmembrane signaling. Applying novel biochemical and molecular biological methods interesting insights into receptor structure/function relationships became available. These studies have a significant impact on our understanding of the molecular basis of human diseases and may eventually lead to novel therapeutic strategies. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 01:00:38