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Titolo:
Clusterin in the male reproductive system: localization and possible function
Autore:
Bailey, R; Griswold, MD;
Indirizzi:
Washington State Univ, Dept Biochem & Biophys, Pullman, WA 99164 USA Washington State Univ Pullman WA USA 99164 Biophys, Pullman, WA 99164 USA
Titolo Testata:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
fascicolo: 1-2, volume: 151, anno: 1999,
pagine: 17 - 23
SICI:
0303-7207(19990525)151:1-2<17:CITMRS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SULFATED GLYCOPROTEIN-2 CLUSTERIN; AMYLOID BETA-PEPTIDE; APOLIPOPROTEIN-A-I; GROWTH-FACTOR-BETA; RETE TESTIS FLUID; RAT SERTOLI CELLS; VENTRAL PROSTATE; GENE-EXPRESSION; HUMAN PLASMA; PROTEIN;
Keywords:
clusterin; male reproductive system; cellular injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Bailey, R Washington State Univ, Dept Biochem & Biophys, Pullman, WA 99164USA Washington State Univ Pullman WA USA 99164 ullman, WA 99164 USA
Citazione:
R. Bailey e M.D. Griswold, "Clusterin in the male reproductive system: localization and possible function", MOL C ENDOC, 151(1-2), 1999, pp. 17-23

Abstract

Clustetin is a glycoprotein that was initially isolated from the male reproductive system. Subsequently, clusterin has been found to be widely distributed in a variety of tissues in mammals. One characteristic of the expression of clusterin is that it is induced as a result of cellular injury, death, or pathology. Despite the efforts of many laboratories working in diverse biological systems, the function of clusterin remains unknown. Recent studies have revealed a 'heat-shock element' in the promoter of the gene that may account for the inducible nature of the clusterin gene. Overall, the evidence suggests that function of clusterin is to protect surviving cells after damage. This protection may result from a detergent-like action of the protein. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 22:56:41