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Titolo:
Adrenergic receptor function in panic disorder II. Neutrophil beta 2 receptors: G(s) protein coupling, effects of imipramine treatment and relationship to treatment outcome
Autore:
Gurguis, GNM; Blakeley, JE; Antai-Otong, D; Vo, SP; Orsulak, PJ; Petty, F; Rush, AJ;
Indirizzi:
Vet Affairs Med Ctr, Lab Clin Neurosci, Dallas, TX 75216 USA Vet Affairs Med Ctr Dallas TX USA 75216 in Neurosci, Dallas, TX 75216 USA Univ Texas, SW Med Sch, Dallas, TX 75230 USA Univ Texas Dallas TX USA 75230 iv Texas, SW Med Sch, Dallas, TX 75230 USA
Titolo Testata:
JOURNAL OF PSYCHIATRIC RESEARCH
fascicolo: 4, volume: 33, anno: 1999,
pagine: 309 - 322
SICI:
0022-3956(199907/08)33:4<309:ARFIPD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRICYCLIC ANTIDEPRESSANT DESIPRAMINE; ADENYLATE-CYCLASE SYSTEM; ANALOGUE MOOD SCALE; LOW-AFFINITY STATES; MESSENGER-RNA; BETA-2-ADRENERGIC RECEPTOR; AGONIST INTERACTIONS; ANXIETY DISORDERS; HEART-RATE; ATYPICAL ANTIDEPRESSANTS;
Keywords:
panic disorder; beta(2)-adrenergic receptor; G(s) protein; coupling; anxiety; antidepressants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
92
Recensione:
Indirizzi per estratti:
Indirizzo: Gurguis, GNM Vet Affairs Med Ctr, Lab Clin Neurosci, Dallas, TX 75216 USA Vet Affairs Med Ctr Dallas TX USA 75216 Dallas, TX 75216 USA
Citazione:
G.N.M. Gurguis et al., "Adrenergic receptor function in panic disorder II. Neutrophil beta 2 receptors: G(s) protein coupling, effects of imipramine treatment and relationship to treatment outcome", J PSYCH RES, 33(4), 1999, pp. 309-322

Abstract

Panic attacks are associated with increased autonomic symptoms, suggestingincreased beta(2)-adrenergic receptor (beta(2)AR) function in PD. Tricyclic antidepressants downregulate beta AR function. Previous studies on beta AR function in PD, however, are inconsistent. We recently found increased beta AR coupling and density in neutrophils of symptomatic drug-free PD patients. This study evaluated beta AR coupling to G(s) protein in 28 controls, 25 drug-free PD patients and 8 PD imipramine-treated patients. PD patients had significantly higher coupling and receptor density, particularly in thehigh-conformational state. Differences were more pronounced in patients with less depressive symptomatology. Treatment with imipramine was associatedwith decreased beta AR coupling and density in the high-conformational state. Several beta AR binding parameters were related to severity of anxiety symptoms and treatment outcome. Antidepressants downregulate beta AR density and induce uncoupling from G(s) protein in PD. Future studies may investigate beta AR coupling in relationship to treatment outcome and the role of beta AR kinase in PD. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:35:51