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Titolo:
Localization of calcitonin gene-related peptide within the genitofemoral nerve in immature rats
Autore:
Schwindt, B; Farmer, PJ; Watts, LM; Hrabovszky, Z; Hutson, JM;
Indirizzi:
Royal Childrens Hosp, Res Inst, F Douglas Stephens Surg Res Lab, Parkville, Royal Childrens Hosp Parkville Vic Australia 3052 urg Res Lab, Parkville,
Titolo Testata:
JOURNAL OF PEDIATRIC SURGERY
fascicolo: 6, volume: 34, anno: 1999,
pagine: 986 - 991
SICI:
0022-3468(199906)34:6<986:LOCGPW>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANCE-P PATHWAY; LUMBAR SPINAL-CORD; TESTICULAR DESCENT; CREMASTER NUCLEUS; ANDROGEN BLOCKADE; FLUTAMIDE; CRYPTORCHIDISM; GUBERNACULUM; IMMUNOREACTIVITIES; CONTRACTILITY;
Keywords:
calcitonin gene-related peptide; genitofemoral nerve; substance P; spinal cord; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Hutson, JM Royal Childrens Hosp, Res Inst, F Douglas Stephens Surg Res Lab, Flemington Royal Childrens Hosp Flemington Rd Parkville Vic Australia 3052
Citazione:
B. Schwindt et al., "Localization of calcitonin gene-related peptide within the genitofemoral nerve in immature rats", J PED SURG, 34(6), 1999, pp. 986-991

Abstract

Background/Purpose: Calcitonin gene-related peptide (CGRP) has been proposed to influence migration and testicular descent by release from the genitofemoral nerve. The site of CGRP within the nerve has been controversial, with conflicting views on whether CGRP is synthesised and released from the motor nerves. Methods: The genitofemoral nerve (GFN) was retrogradely labelled by fluorescent dye (DAPI) in 25 Sprague-Dawley rats (days 5, 16, and 31, n = 8 in each group; day 35, n = 1), Spinal cords and dorsal root ganglia (DRG) were removed two to three days later and sectioned far immunofluorescence. Substance P and CGRP-containing cells were labelled with fluorescein-linked antibodies. Specimens were examined by double fluorescence to identify cells with both markers. Results: The motor nucleus of the GFN contained 1 19 cells on day 7 and 284 cells by days 19 through 34. A prominent band of CGRP-containing fibers, arising from the dorsal horn, synapsed with the GFN motor nucleus itself. CGRP-labelled GFN cells were found in the DRG by double labelling. Conclusions: CGRP from the GFN may affect gubernacular migration by release from the sensory nerves, rather than motor nerves as previously thought. The GFN motor nucleus receives CGRP-containing innervation from the dorsal horn, which may form part of the cremasteric reflex. J Pediatr Surg 34:986-991. Copyright (C) 1999 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:45:42