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Titolo:
Hepatitis C virus-related fibrosing cholestatic hepatitis after cardiac transplantation - Is azathioprine a contributory factor?
Autore:
Delgado, J; de Bustillo, EM; Ibarrola, C; Colina, F; Morales, JM; Rodriguez, E; Aguado, JM; Fuertes, A; Gomez, MA;
Indirizzi:
HospSpainctubre, Dept Anat Patol, Heart Transplantat Unit, E-28041 Madrid,Hosp 12 Octubre Madrid Spain E-28041 Transplantat Unit, E-28041 Madrid,
Titolo Testata:
JOURNAL OF HEART AND LUNG TRANSPLANTATION
fascicolo: 6, volume: 18, anno: 1999,
pagine: 607 - 610
SICI:
1053-2498(199906)18:6<607:HCVFCH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECIPIENTS; PATIENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
5
Recensione:
Indirizzi per estratti:
Indirizzo: Colina, F Hospm12 Octubre, Dept Anat Patol, Heart Transplantat Unit, Ctra Andalucia K Hosp 12 Octubre Ctra Andalucia Km 5400 Madrid Spain E-28041 a K
Citazione:
J. Delgado et al., "Hepatitis C virus-related fibrosing cholestatic hepatitis after cardiac transplantation - Is azathioprine a contributory factor?", J HEART LUN, 18(6), 1999, pp. 607-610

Abstract

We report a patient who acquired hepatitis C virus (HCV) infection at cardiac transplantation, developing fibrosing cholestatic hepatitis (FCH) with early liver failure and a fatal outcome. FCH is a recently described clinicopathological entity characterized by a cholestatic pattern of serum liver enzyme abnormalities, a progressive course leading to liver failure, and a pathological picture defined by periportal fibrosis, neutrophilic infiltrates and signs of histological cholestasis. Although it was initially described secondary to hepatitis B virus infection, it has also been recently related to HCV infection. Some histopathological features consistent with azathioprine hepatotoxicity like cholestasis, perisinusoidal fibrosis, veno-subocclusive lesions and nodular regenerative hyperplasia were also observed inthis case. Therefore, a direct cytopathic effect of HCV and the concurrentpathogenic role of azathioprine hepatotoxicity may be involved in the development of this complication of transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:09:58