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Titolo:
A new rejection criteria in the heterotopically placed rat heart by non-invasive measurement of Dp/Dt(max)
Autore:
Dambrin, C; El Feghaly, M; Abbal, M; Glock, Y; Durand, D; Fournial, G; Ohayon, E; Cerene, A;
Indirizzi:
Rangueil Hosp, Dept Cardiovasc Surg, F-31043 Toulouse, France Rangueil Hosp Toulouse France F-31043 asc Surg, F-31043 Toulouse, France
Titolo Testata:
JOURNAL OF HEART AND LUNG TRANSPLANTATION
fascicolo: 6, volume: 18, anno: 1999,
pagine: 524 - 531
SICI:
1053-2498(199906)18:6<524:ANRCIT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC ALLOGRAFT-REJECTION; XENOGRAFT SURVIVAL; TRANSPLANTATION; PROLONGATION; INOCULATION; INHIBITION; MODEL; BLOOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Dambrin, C Rangueilrance, Dept Cardiovasc Surg, 1 AV Jean Poulhes, F-31043Toulouse, F Rangueil Hosp 1 AV Jean Poulhes Toulouse France F-31043 use, F
Citazione:
C. Dambrin et al., "A new rejection criteria in the heterotopically placed rat heart by non-invasive measurement of Dp/Dt(max)", J HEART LUN, 18(6), 1999, pp. 524-531

Abstract

Background: The heterotopic heart of rats has been a useful model in the evaluation of immunomodulatory protocols. Graft palpation usually determinesthe day of rejection. We present in this paper an original method of graftmonitoring in allograft rejection. Methods: Heterotopic cardiac abdominal transplantation was performed in Lewis isografts (n = 15) and in ACI to Lewis allograft(n = 15). A balloon;connected to a measurement device was inserted in the left ventricle, and calculation of Dp/Dt(max) was possible by recording the intra-left ventricular pressure.;A ten-day follow-up was achieved with a daily comparison of palaption, EGG, and Dp/Dt(max),Results: In transplanted hearts, Dp/Dt(max) did not change in isografts but significantly decreased in allograft on posttransplantation Day 5 (PTD 5)vs PTD 0.1 and 3 (p < .01). Dp/Dt(max) values on PTD 5 and 6 were also Statistically significant in allograft vs isograft group (p < .01). Histological analysis at this time showed the occurrence of acute rejection in the allograft group. Graft palpation; and ECG remained normal until PTD 10 and nodifference was observed between iso and allo groups. Conclusion: This study shows that daily measurement of Dp/Dt(max) in heterotopic heart is made possible by our implantable system without interrupting the graft, and gives a more accurate definition of graft rejection than acombination of palpation and EGG. In addition, this method would seem desirable when differences in survival may be expected to be of lesser magnitude.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:50:38