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Titolo:
Sensitive and selective liquid chromatographic assay of memantine in plasma with fluorescence detection after pre-column derivatization
Autore:
Suckow, RF; Zhang, MF; Collins, ED; Fischman, MW; Cooper, TB;
Indirizzi:
NathanYS Kline Inst Psychiat Res, Analyt Psychopharmacol Lab, Orangeburg, N Nathan S Kline Inst Psychiat Res Orangeburg NY USA 10962 b, Orangeburg, N New2York State Psychiat Inst, Analyt Psychopharmacol Lab, New York, NY 1003 New York State Psychiat Inst New York NY USA 10032 Lab, New York, NY 1003 Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 729, anno: 1999,
pagine: 217 - 224
SICI:
1387-2273(19990611)729:1-2<217:SASLCA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ANTAGONIST; PARKINSONS-DISEASE; OPIOID TOLERANCE; URINE; RIMANTADINE; AMANTADINE; DEPENDENCE; EFFICACY;
Keywords:
memantine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Suckow, RF Nathaneburgine Inst Psychiat Res, Analyt Psychopharmacol Lab, 140 Old Orang Nathan S Kline Inst Psychiat Res 140 Old Orangeburg Rd Orangeburg NY USA 10962
Citazione:
R.F. Suckow et al., "Sensitive and selective liquid chromatographic assay of memantine in plasma with fluorescence detection after pre-column derivatization", J CHROMAT B, 729(1-2), 1999, pp. 217-224

Abstract

A procedure was developed for the determination of memantine in plasma using liquid chromatography with fluorescence detection. Following a liquid-liquid extraction from 1 ml of plasma containing the internal standard amantadine, the extract was derivatized at room temperature with dansyl chloride,and the highly fluorescent derivatives were chromatographed with a reversed-phase C-18 column and a mobile phase of phosphate buffer and acetonitrile. Dansylated memantine and amantadine were eluted in less than 13 min with no interference from endogenous material. The calibration curve was Linear over the concentration range of 3-400 ng/ml with inter- and intra-assay imprecision (C.V.) of less than 10%. The limit of quantitation was 3 ng/ml, and no major antidepressant, neuroleptic or their respective metabolites interfered with the quantitation of memantine. This method could also be applied to the quantitation of amantadine. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 12:11:10