Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Molecular moment similarity between several nucleoside analogs of thymidine and thymidine
Autore:
Silverman, BD; Pitman, MC; Platt, DE;
Indirizzi:
IBM, Thomas J Watson Res Ctr, Valhalla, NY 10595 USA IBM Valhalla NY USA 10595 Thomas J Watson Res Ctr, Valhalla, NY 10595 USA
Titolo Testata:
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
fascicolo: 6, volume: 16, anno: 1999,
pagine: 1169 - 1175
SICI:
0739-1102(199906)16:6<1169:MMSBSN>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-REPLICATION; DIFLUOROTOLUENE; ADENINE; LACKING; PAIR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Silverman, BD IBM, Thomas J Watson Res Ctr, Valhalla, NY 10595 USA IBM Valhalla NY USA 10595 n Res Ctr, Valhalla, NY 10595 USA
Citazione:
B.D. Silverman et al., "Molecular moment similarity between several nucleoside analogs of thymidine and thymidine", J BIO STRUC, 16(6), 1999, pp. 1169-1175

Abstract

Molecular moment descriptors of the shape and charge distributions of twenty five nucleoside structures have been examined. The structures include thymidine as well as the difluorotoluene nucleoside analog which has been found to pair efficiently with adenine by polymerase catalysis. The remaining twenty three structures have been chosen to be as structurally similar to thymidine and to the difluorotoluene nucleoside analog as possible. The moment descriptors which include a description of the relationship of molecularcharge to shape show the difluorotoluene nucleoside to be one of the most proximate molecules to thymidine in the space of the molecular moments. Thecalculations, therefore, suggest that polymerase specificity might be not only a consequence of molecular steric features alone but also of the molecular electrostatic environment and its registration with molecular shape.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 03:56:16