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Titolo:
Clonazepam release from bioerodible hydrogels based on semi-interpenetrating polymer networks composed of poly(epsilon-caprolactone) and poly(ethylene glycol) macromer
Autore:
Cho, CS; Han, SY; Ha, JH; Kim, SH; Lim, DY;
Indirizzi:
Seoul441744,niv, Coll Agr & Life Sci, Div Biol Resources & Mat Engn, SuwonSeoul Natl Univ Suwon South Korea 441744 iol Resources & Mat Engn, Suwon Chosun Univ, Coll Pharm, Kwangju 501759, South Korea Chosun Univ KwangjuSouth Korea 501759 harm, Kwangju 501759, South Korea Chosun Univ, Coll Med, Dept Pharmacol, Kwangju 501759, South Korea Chosun Univ Kwangju South Korea 501759 acol, Kwangju 501759, South Korea
Titolo Testata:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
fascicolo: 2, volume: 181, anno: 1999,
pagine: 235 - 242
SICI:
0378-5173(19990430)181:2<235:CRFBHB>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Keywords:
clonazepam release; bioerodible hydrogel; poly(ethylene glycol) macromer; semi-interpenetrating polymer network;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Cho, CS Seoulrdoon Univ, Coll Agr & Life Sci, Div Biol Resources & Mat Engn, 103 Se Seoul Natl Univ 103 Serdoon Dong,Kwonsun Ku Suwon South Korea 441744
Citazione:
C.S. Cho et al., "Clonazepam release from bioerodible hydrogels based on semi-interpenetrating polymer networks composed of poly(epsilon-caprolactone) and poly(ethylene glycol) macromer", INT J PHARM, 181(2), 1999, pp. 235-242

Abstract

Poly(ethylene glycol)(PEG) macromers terminated with acrylate groups and semi-interpenetrating polymer networks (SIPNs) composed of poly(epsilon-caprolactone)(PCL) and PEG macromer were synthesized to obtain a bioerodible hydrogel. Polymerization of PEG macromer resulted in the formation of cross-linked gels due to the multifunctionality of macromer. Glass transition temperature (T-g) and melting temperature (T-m) of PEG networks and PCL in the SIPNs were inner-shifted, indicating an interpenetration of PCL and PEG chains. Water content in the SIPNs increased with increasing PEG weight fraction due to the hydrophilicity of PEG. The amount of clonazepam (CNZ) released from the SIPNs increased with higher content in the SIPNs, lower drug loading, lower concentration of PEG macromer during the SIPNs preparation, andhigher molecular weight of PEG. In particular, a combination with low PEG content and low CNZ solubility in water led to long-term constant release from these matrices in vitro and in vivo. (C) 1999 Elsevier Science B.V. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:52:26