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Titolo:
Cerium-doped diosmectite for topical application studies of the cerium-clay interaction
Autore:
Papin-Castela, N; Prognon, P; Keller, F; Benazeth, S; Farinotti, R; Mahuzier, G; Souleau, C;
Indirizzi:
Univ Paris 11, Fac Pharm, Lab Pharm Clin, F-92296 Chatenay Malabry, FranceUniv Paris 11 Chatenay Malabry France F-92296 6 Chatenay Malabry, France Univ Paris 11, Fac Pharm, Chim Analyt Lab, F-92296 Chatenay Malabry, France Univ Paris 11 Chatenay Malabry France F-92296 6 Chatenay Malabry, France Univenayis 11, Fac Pharm, Lab Chim Phys Minerale & Bioinorgan, F-92296 Chat Univ Paris 11 Chatenay Malabry France F-92296 & Bioinorgan, F-92296 Chat Univ Paris 06, Fac Pharm, Lab Biomath, F-75006 Paris, France Univ Paris 06 Paris France F-75006 m, Lab Biomath, F-75006 Paris, France
Titolo Testata:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
fascicolo: 2, volume: 181, anno: 1999,
pagine: 193 - 202
SICI:
0378-5173(19990430)181:2<193:CDFTAS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SILVER SULFADIAZINE; POSTBURN IMMUNOSUPPRESSION; ANIMAL-MODEL; NITRATE; ANTACIDS;
Keywords:
cerium; clay; diosmectite; cerium sorption; release studies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Papin-Castela, N Univ Paris 11, Fac Pharm, Lab Pharm Clin, F-92296 Chatenay Malabry, France Univ Paris 11 Chatenay Malabry France F-92296 y, France
Citazione:
N. Papin-Castela et al., "Cerium-doped diosmectite for topical application studies of the cerium-clay interaction", INT J PHARM, 181(2), 1999, pp. 193-202

Abstract

Cerium is used for its antiseptic and immunomodulatory properties in burn injury. We have developed a cerium-doped clay to replace existing ointments. Adsorption and release of cerium (Ce3+) by diosmectite were studied at 22+/- 2 degrees C, in the presence of various other cationic species. Simplespectrofluorimetric determination of cerium was used (lambda exc = 240 nm/lambda em = 360 nm). Cerium binding reached a plateau within 2 min and was a function of the electrolyte content of the solution in contact with the clay. Langmuir isotherm treatment led to a maximal binding capacity of 66 mgof Ce3+ per gram of clay. Partial release occurred within 2 min (19%. in the presence of isotonic NaCl solution). The ionic strength of the solution,and the ionic radius and charge of the electrolytes present in the bathingsolution significantly influenced cerium release, in contrast to pH and temperature changes. These results strongly point to a cationic exchange mechanism between diosmectite and cerium solution. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:14:25