Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Increased blood vessel density in decidua parietalis is associated with spontaneous human first trimester abortion
Autore:
Vailhe, B; Dietl, J; Kapp, M; Toth, B; Arck, P;
Indirizzi:
Univ Grenoble 1, Grenoble, France Univ Grenoble 1 Grenoble FranceUniv Grenoble 1, Grenoble, France Univ Wurzburg, Frauenklin, D-8700 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-8700 auenklin, D-8700 Wurzburg, Germany Humboldt Univ, D-1086 Berlin, Germany Humboldt Univ Berlin Germany D-1086 umboldt Univ, D-1086 Berlin, Germany
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 6, volume: 14, anno: 1999,
pagine: 1628 - 1634
SICI:
0268-1161(199906)14:6<1628:IBVDID>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE-1; VASCULAR ENDOTHELIAL-CELLS; NORMAL MENSTRUAL-CYCLE; INTEGRIN ALPHA(V)BETA(3); IFN-GAMMA; HUMAN CYTOTROPHOBLASTS; MICROVASCULAR DENSITY; ENDOVASCULAR INVASION; VONWILLEBRAND-FACTOR; TNF-ALPHA;
Keywords:
angiogenesis; decidua basalis and parietalis; human pregnancy; spontaneous abortion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Arck, P BiomedKlinikum,Augustenburger Klin Schwerpunkt Psychosomat, CampusVirchow Biomed Forschungszentrum Campus Virchow Klinikum,Augustenburger Pl1 Berlin Germany D-13353
Citazione:
B. Vailhe et al., "Increased blood vessel density in decidua parietalis is associated with spontaneous human first trimester abortion", HUM REPR, 14(6), 1999, pp. 1628-1634

Abstract

Spontaneous pregnancy loss affects 15-18% of couples, and a number of potential causes are being discussed. The purpose of the present study was to assess if angiogenic disorders in the decidua of early human pregnancy couldbe related to spontaneous abortions. First trimester human decidua from elective terminations of normally progressing pregnancies and from missed abortions were investigated immunohistochemically. We quantified vessel density in decidua from normal pregnancies and from abortions by von Willebrand factor (vWF), platelet endothelial cell adhesion molecule (PECAM-1) and CD34staining. Decidual blood vessel expression of alpha v beta 3 integrin was also investigated. Significant increase (P < 0.02) in vessel density was observed in decidua parietalis of abortions, compared to decidua basalis. This increase was detected on slides stained for VWF and CD34, but not for PECAM-1. We observed a 15% increase analysing with vWF and a 77% increase withCD34 staining. alpha v beta 3 integrin expression was not significantly different, neither in decidua parietalis from abortion, nor parietalis from normal pregnancies. Our data suggest that the increased vascularization in decidua parietalis from abortions could reflect complex disorders, such as specific cytokine expressions and hypoxia phenomena during the development of the decidua.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 04:34:50