Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of in-utero diethylstilboestrol exposure on human oocyte quality and fertilization in a programme of in-vitro fertilization
Autore:
Kerjean, A; Poirot, C; Epelboin, S; Jouannet, P;
Indirizzi:
Univ Paris 05, Hop Cochin, Reprod Biol Lab, F-75014 Paris, France Univ Paris 05 Paris France F-75014 eprod Biol Lab, F-75014 Paris, France Hop St Vincent de Paul, Serv Gynecol Obstet, F-75014 Paris, France Hop St Vincent de Paul Paris France F-75014 bstet, F-75014 Paris, France
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 6, volume: 14, anno: 1999,
pagine: 1578 - 1581
SICI:
0268-1161(199906)14:6<1578:EOIDEO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENITAL-TRACT CHANGES; INVITRO FERTILIZATION; DIETHYLSTILBESTROL INUTERO; WOMEN; PREGNANCY; INFERTILITY; EXPERIENCE; DAUGHTERS;
Keywords:
diethylstilboestrol; embryo; infertility; in-vitro fertilization; oocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Poirot, C Univs,aris 05, Hop Cochin, Reprod Biol Lab, 123 Bd Port Royal, F-75014 Pari Univ Paris 05 123 Bd Port Royal Paris France F-75014 75014 Pari
Citazione:
A. Kerjean et al., "Effect of in-utero diethylstilboestrol exposure on human oocyte quality and fertilization in a programme of in-vitro fertilization", HUM REPR, 14(6), 1999, pp. 1578-1581

Abstract

Genital tract abnormalities and adverse pregnancy outcome are well known in women exposed in utero to diethylstilboestrol (DES), Data about adverse reproductive performance in women exposed to DES have been published, including controversial reports of menstrual dysfunction, poor responses after ovarian stimulation, oocyte maturation and fertilization abnormalities. We compared oocyte quality, in-vitro fertilization results and embryo quality for women exposed in utero to DES with a control group. Between 1989 and 1996, 56 DES-exposed women who had 125 in-vitro fertilization (IVF) attempts were retrospectively compared to a control group of 45 women with tubal disease, who underwent 73 IVF attempts. Couples suffering from male infertility were excluded. The parameters compared were oocyte quality (maturation abnormalities, immature oocyte, mature oocyte), fertilization and cleavage rate(per treated and metaphase II oocytes), and embryo quality (number and grade). We found no significant difference in oocyte maturational status, fertilization rates, cleavage rates, embryo quality and development between DES-exposed subjects and control subjects. These results suggest that in-uteroexposure to DES has no significant influence on oocyte quality and fertilization ability as judged during IVF attempts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:02:09