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Titolo:
The differential risk of oral contraceptives: the impact of full exposure history
Autore:
Lewis, MA; MacRae, KD; Kuhl-Habich, D; Bruppacher, R; Heinemann, LAJ; Spitzer, WO;
Indirizzi:
EPES Epidemiol Pharmacoepidemiol & Syst Res, D-12165 Berlin, Germany EPES Epidemiol Pharmacoepidemiol & Syst Res Berlin Germany D-12165 rmany Univ Kansas, Med Ctr, Dept Prevent Med, Kansas City, KS 66103 USA Univ Kansas Kansas City KS USA 66103 event Med, Kansas City, KS 66103 USA Univ Potsdam, Potsdam, Germany Univ Potsdam Potsdam GermanyUniv Potsdam, Potsdam, Germany Ctr Epidemiol & Hlth Res ZEG, Zepernick, Germany Ctr Epidemiol & Hlth Res ZEG Zepernick Germany ZEG, Zepernick, Germany McGill Univ, Dept Epidemiol & Biostat, Montreal, PQ, Canada McGill Univ Montreal PQ Canada Epidemiol & Biostat, Montreal, PQ, Canada Univ Basel, Dept Prevent Med, Basel, Switzerland Univ Basel Basel Switzerland asel, Dept Prevent Med, Basel, Switzerland
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 6, volume: 14, anno: 1999,
pagine: 1493 - 1499
SICI:
0268-1161(199906)14:6<1493:TDROOC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENOUS THROMBOEMBOLISM; WOMEN; PROGESTAGENS;
Keywords:
case-control study; Cox regression analysis; epidemiology; oral contraceptive use; venous thromboembolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Lewis, MA EPESrmanyemiol Pharmacoepidemiol & Syst Res, Wulffstr 8, D-12165Berlin, Ge EPES Epidemiol Pharmacoepidemiol & Syst Res Wulffstr 8 Berlin Germany D-12165
Citazione:
M.A. Lewis et al., "The differential risk of oral contraceptives: the impact of full exposure history", HUM REPR, 14(6), 1999, pp. 1493-1499

Abstract

Previous discussions have indicated that the small increases of risk of venous thromboembolism (VTE) associated with newer combined oral contraceptives (third generation, containing desogestrel and gestodene) may be attributed to bias due to cohort effects. In a case-control analysis, this may produce an overestimate of risk of newer preparations. In 10 centres in Germanyand the UK, the Transnational Study analysed data from 502 women aged 16-44 years with VTE, and from 1864 controls matched for 5-year age group and region. Information on lifetime exposure history from all subjects was addedto the dataset used in previous analyses and entered into a Cox regressionmodel with time-dependent covariates. Based on 17 622 continuous exposure episodes comprising 47 914 person-years of observation, the adjusted hazardratio (equivalent to odds ratio, OR) of VTE for the comparison of current users of third-generation versus current users of second-generation (primarily levonorgestrel compounds) combined oral contraceptives was 0.8 (0.5 to 1.3). The OR obtained in standard case-control analysis had been 1.5 (1.1 to 2.1). Adjustment for past exposures includes more information and appearsmore valid than the standard cross-sectional analysis, Using this approach, the Transnational Study data show no evidence for an increased risk of VTE with third- compared with second-generation combined oral contraceptives.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:38:31